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Hyaluronic Acid as a LYVE-1 Receptor Ligand in the Lymphatic System of Healthy Human Skin

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Immunohistochemical detection of the LYVE-1 marker in healthy human full-thickness skin (the epidermis and the dermis) was carried out. LYVE-1 expression was found in the endothelium of lymphatic capillaries located in the papillary dermis, in the endothelium of larger lymphatic vessels of the reticular dermis, and in fibroblasts, which indicates their joint participation in hyaluronan metabolism. LYVE-1+ staining detected for the first time in cells of the stratum basale, the stratum spinosum, and the stratum granulosum of healthy human epidermis indicates their participation in hyaluronan metabolism and allows us to consider the spaces between epidermis cells as prelimphatics.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lympho-logy — Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia

    S. V. Michurina, N. N. Svechnikova, V. I. Konenkov, I. Yu. Ishchenko, S. A. Arkhipov & V. V. Arkhipova

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  1. S. V. Michurina
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  2. N. N. Svechnikova
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  3. V. I. Konenkov
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  4. I. Yu. Ishchenko
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  5. S. A. Arkhipov
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  6. V. V. Arkhipova
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Correspondence to S. V. Michurina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 11, pp. 659-663, November, 2023

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Michurina, S.V., Svechnikova, N.N., Konenkov, V.I. et al. Hyaluronic Acid as a LYVE-1 Receptor Ligand in the Lymphatic System of Healthy Human Skin. Bull Exp Biol Med 176, 636–639 (2024). https://doi.org/10.1007/s10517-024-06083-2

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  • DOI: https://doi.org/10.1007/s10517-024-06083-2

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