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Analgesic and Psychotropic Effects of a New Bradykinin Antagonist

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Bulletin of Experimental Biology and Medicine Aims and scope

A bradykinin B1 receptors antagonist PAV-0056, an 1,4-benzodiazepin-2-one derivative, intragastrically administrated to mice at doses of 0.1 and 1 mg/kg causes analgesia in the “formalin test” not inferior to that of diclofenac sodium (10 mg/kg) and tramadol (20 mg/kg). PAV-0056 at doses of 0.1 and 10 mg/kg has no anxiolytic and central muscle relaxant effects in mice and does not damage the gastric mucosa in rats. Based on the results of the conditioned place preference test, PAV-0056 also does not induce addiction in mice.

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Authors and Affiliations

  1. Innovative Pharmacology Research LLC, Tomsk, Russia

    A. E. Aliforenko, V. S. Motov, V. V. Bykov, A. V. Bykova, V. I. Pavlovsky, V. V. Larchenko & V. A. Khazanov

  2. Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    A. E. Aliforenko, V. V. Bykov, V. V. Larchenko & A. I. Vengerovskii

Authors
  1. A. E. Aliforenko
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  2. V. S. Motov
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  3. V. V. Bykov
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  4. A. V. Bykova
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  5. V. I. Pavlovsky
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  6. V. V. Larchenko
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  7. V. A. Khazanov
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  8. A. I. Vengerovskii
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Corresponding author

Correspondence to V. V. Bykov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 11, pp. 595-599, November, 2023

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Aliforenko, A.E., Motov, V.S., Bykov, V.V. et al. Analgesic and Psychotropic Effects of a New Bradykinin Antagonist. Bull Exp Biol Med 176, 581–584 (2024). https://doi.org/10.1007/s10517-024-06071-6

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  • DOI: https://doi.org/10.1007/s10517-024-06071-6

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