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Features of Intracellular Signal Transduction in Neural Stem Cells under the Influence of Alkaloid Songorine, an Agonist of Fibroblast Growth Factor Receptors

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We performed a comparative in vitro study of the involvement of NF-κB, PI3K, cAMP, ERK1/2, p38, JAKs, STAT3, JNK, and p53-dependent intracellular signaling in the functioning of neural stem cells (NSC) under the influence of basic fibroblast growth factor (FGF) and FGF receptor agonist, diterpene alkaloid songorine. The significant differences in FGFR-mediated intracellular signaling in NSC were revealed for these ligands. In both cases, stimulation of progenitor cell proliferation occurs with the participation of NF-κB, PI3K, ERK1/2, JAKs, and STAT3, while JNK and p53, on the contrary, inhibit cell cycle progression. However, under the influence of songorin, cAMP- and p38-mediated cascades are additionally involved in the transmission of the NSC division-activating signal. In addition, unlike FGF, the alkaloid stimulates progenitor cell differentiation by activating ERK1/2, p38, JNK, p53, and STAT3.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    G. N. Zyuz’kov, E. A. Losev, N. I. Suslov, L. A. Miroshnichenko, T. Yu. Polyakova, E. V. Simanina, L. A. Stavrova, V. I. Agafonov, M. G. Danilets & V. V. Zhdanov

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  1. G. N. Zyuz’kov
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  2. E. A. Losev
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  3. N. I. Suslov
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  4. L. A. Miroshnichenko
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  5. T. Yu. Polyakova
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  6. E. V. Simanina
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  7. L. A. Stavrova
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  8. V. I. Agafonov
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  9. M. G. Danilets
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  10. V. V. Zhdanov
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Correspondence to G. N. Zyuz’kov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 11, pp. 589-594, November, 2023

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Zyuz’kov, G.N., Losev, E.A., Suslov, N.I. et al. Features of Intracellular Signal Transduction in Neural Stem Cells under the Influence of Alkaloid Songorine, an Agonist of Fibroblast Growth Factor Receptors. Bull Exp Biol Med 176, 576–580 (2024). https://doi.org/10.1007/s10517-024-06070-7

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  • DOI: https://doi.org/10.1007/s10517-024-06070-7

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