Skip to main content

Advertisement

SpringerLink
Log in

Features of Interferon Status and Methods of Its Correction in the Treatment of Patients with Atypical Chronic Active Herpesvirus Infections

  • IMMUNOLOGY AND MICROBIOLOGY
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

It is known that the imbalance of the IFN system is the cornerstone of the immunopathogenesis of atypical chronic active herpesvirus infections and is often associated not only with congenital, genetically determined defects, but also with acquired system dysregulation at different levels: receptor, molecular, at the level of a nuclear transducer of signal transmission. Based on the studied features of immunopathogenesis and the revealed disturbances in the antiviral immune defense system and the IFN system in patients with atypical chronic herpes viral infections, an integration program for correcting IFN status was developed, its clinical and immunological effectiveness was evaluated. Improved effectiveness of complex rehabilitation of immunocompromised patients with atypical chronic active herpes viral infections was demonstrated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Nesterova IV, Kovaleva SV, Chudilova GA, Khalturina EO, Malinovskaya VV. Congenital and Acquired Interferonopathies Associated with Atypical Viral Infections and COVID-19. St. Petersburg, 2022. Russian.

  2. Khalturina EO, Nesterova IV, Markova TP. An optimized program of targeted combined interferon- and immunotherapy in the treatment of atypical chronic active herpesvirus co-infections. Effekt. Farmakoter. 2022;18(12):58-63. Russian.

  3. Goreiko TV, Kalinina NM, Drygina LV. The modern conceptions about immunopathogenesis of infection caused by the Epstein—Barr virus. Infeltsiya Immunitet. 2011;1(2):121-130. Russian. doi: https://doi.org/10.15789/2220-7619-2011-2-121-130

  4. Akmeeva AS, Zhamborova RB, Aloeva AYa, Kakhidov AI, Abdulkadyrova ID, Altamirova DM, Kambachokova ZA, Tagirova TSh, Elias AE. Cytokine status in patients with recurrent herpes infection. Antibiotiki Khimioterapiya. 2021;66(5-6):35-39. Russian. doi: https://doi.org/10.37489/0235-2990-2021-66-5-6-35-39

  5. Baskakova DV, Khaldin AA, Birko NI. Clinical and epidemiological characteristics of diseased caused by herpes simplex virus. Ross. Zh. Kozhn. Venerich. Bolezn. Pril. Gerpes. 2006;(2):26-30. Russian.

  6. Jiang J, Zhao M, Chang C, Wu H, Lu Q. Type I Interferons in the pathogenesis and treatment of autoimmune diseases. Clin. Rev. Allergy Immunol. 2020;59(2):248-272. doi: https://doi.org/10.1007/s12016-020-08798-2

    Article  CAS  PubMed  Google Scholar 

  7. Zheng C, Zhou XW, Wang JZ. The dual roles of cytokines in Alzheimer’s disease: update on interleukins, TNF-α, TGF-β and IFN-γ. Transl. Neurodegener. 2016;5:7. doi: https://doi.org/10.1186/s40035-016-0054-4

    Article  CAS  PubMed  Google Scholar 

  8. Novikova IA, Romaniva OA. Features of cytokine production in patients with recurrent herpetic infection. Med. Immunol. 2013;15(6):571-576. Russian.

  9. Olson L, Humpel C. Growth factors and cytokines/chemokines as surrogate biomarkers in cerebrospinal fluid and blood for diagnosing Alzheimer’s disease and mild cognitive impairment. Exp. Gerontol. 2010;45(1):41-46. doi: https://doi.org/10.1016/j.exger.2009.10.011

    Article  CAS  PubMed  Google Scholar 

  10. Pandya SY, Lacritz LH, Weiner MF, Deschner M, Woon FL. Predictors of reversion from mild cognitive impairment to normal cognition. Dement. Geriatr. Cogn. Disord. 2017;43(3-4):204-214. doi: https://doi.org/10.1159/000456070

    Article  PubMed  Google Scholar 

  11. Michaud TL, Su D, Siahpush M, Murman DL. The risk of incident mild cognitive impairment and progression to dementia considering mild cognitive impairment subtypes. Dement. Geriatr. Cogn. Dis. Extra. 2017;7(1):15-29. doi: https://doi.org/10.1159/000452486

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

    E. O. Khalturina

  2. Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia

    I. V. Nesterova

Authors
  1. E. O. Khalturina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. V. Nesterova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. O. Khalturina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 6, pp. 751-754, June, 2023

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Khalturina, E.O., Nesterova, I.V. Features of Interferon Status and Methods of Its Correction in the Treatment of Patients with Atypical Chronic Active Herpesvirus Infections. Bull Exp Biol Med 175, 791–793 (2023). https://doi.org/10.1007/s10517-023-05948-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-023-05948-2

Keywords

Search

Navigation