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Angiogenin as a Possible Mediator of Macrophage-Mediated Regulation of Fibroblast Functions

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We studied angiogenin production by human macrophages and evaluated the role of this factor in the macrophage-mediated regulation of fibroblasts. All macrophage subtypes, and especially the efferocytosis-polarized macrophages, M2(LS), actively produced angiogenin. Exogenous recombinant angiogenin dose-dependently enhanced the proliferation and differentiation of dermal fibroblasts. The addition of the angiogenin inhibitor to fibroblasts cultures suppressed the stimulating effect of exogenous angiogenin or M2(LS) conditioned media. These findings indicate the involvement of angiogenin in the macrophage-mediated paracrine regulation of skin fibroblasts.

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Authors and Affiliations

  1. Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia

    A. A. Maksimova, E. Ya. Shevela, M. A. Tikhonova, T. V. Tyrinova, A. A. Ostanin & E. R. Chernykh

  2. Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    S. S. Bogachev

Authors
  1. A. A. Maksimova
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  2. E. Ya. Shevela
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  3. M. A. Tikhonova
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  4. T. V. Tyrinova
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  5. S. S. Bogachev
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  6. A. A. Ostanin
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  7. E. R. Chernykh
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Correspondence to A. A. Maksimova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 5, pp. 597-601, May, 2023

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Maksimova, A.A., Shevela, E.Y., Tikhonova, M.A. et al. Angiogenin as a Possible Mediator of Macrophage-Mediated Regulation of Fibroblast Functions. Bull Exp Biol Med 175, 658–661 (2023). https://doi.org/10.1007/s10517-023-05921-z

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  • DOI: https://doi.org/10.1007/s10517-023-05921-z

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