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Assessment of Ante- and Postnatal Development of the Offspring of Male Rats Crossed in Delayed Periods after Treatment with Methotrexate in Low Doses

  • EXPERIMENTAL BIOLOGY
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We studied ante- and postnatal development of the offspring of intact female rats crossed with males injected with low doses of methotrexate 3 and 6 months before mating. The time of crossing corresponded to the manifestation of the cytostatic effect on spermatogonial stem cells. The offspring of methotrexate-treated males was characterized by increased preimplantation losses and fetal growth restriction in the antenatal period and inhibition of physical development, delayed formation of sensory-motor reflexes, and impaired learning abilities in the postnatal period.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    T. G. Borovskaya, E. A. Bokhan, A. V. Vychuzhanina & Yu.A. Shchemerova

  2. Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    V. E. Goldberg

Authors
  1. T. G. Borovskaya
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  2. E. A. Bokhan
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  3. A. V. Vychuzhanina
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  4. Yu.A. Shchemerova
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  5. V. E. Goldberg
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Corresponding author

Correspondence to T. G. Borovskaya.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 4, pp. 506-511, April, 2023

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Borovskaya, T.G., Bokhan, E.A., Vychuzhanina, A.V. et al. Assessment of Ante- and Postnatal Development of the Offspring of Male Rats Crossed in Delayed Periods after Treatment with Methotrexate in Low Doses. Bull Exp Biol Med 175, 503–507 (2023). https://doi.org/10.1007/s10517-023-05895-y

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  • DOI: https://doi.org/10.1007/s10517-023-05895-y

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