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Pharmacological Effects of a New Indolinone Derivative in Experimental Pneumonitis in Rats

  • PHARMACOLOGY AND TOXICOLOGY
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We studied the effect of a new indolinone derivative GRS on animal survival and on functioning and histological structure of the lungs in rats with experimental pneumonitis. The rats of experimental groups were intratracheally administered 0.5% aqueous solution of carrageenan under intramuscular anesthesia. Compound GRS (10 mg/kg; a suspension in 0.5% aqueous solution of carboxymethyl cellulose) was orally administered for 4 days starting from the day of carrageenan administration; another rat group received the aqueous solution of carboxymethyl cellulose alone. Control rats received intratracheally isotonic solution of sodium chloride. Animal mortality was registered over 5 days; on day 5, the respiratory parameters were measured, the lungs were weighed, pulmonary edema was evaluated, and histological structure of the lungs was studied. GRS compound improved survival of animals with modeled pneumonitis, restored the respiratory parameters to the level of control animals, and reduced pulmonary edema by 35% and the severity of histological damage score in the lungs by 17% (p<0.05).

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Authors and Affiliations

  1. LLC Innovative Pharmacology Research, Tomsk, Russia

    V. V. Bykov, V. S. Motov, A. V. Bykova & V. A. Khazanov

  2. Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    V. V. Bykov & A. I. Vengerovskii

  3. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    V. V. Udut

Authors
  1. V. V. Bykov
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  2. V. S. Motov
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  3. A. V. Bykova
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  4. V. A. Khazanov
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  5. A. I. Vengerovskii
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  6. V. V. Udut
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Correspondence to V. V. Bykov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 4, pp. 457-461, April, 2023

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Bykov, V.V., Motov, V.S., Bykova, A.V. et al. Pharmacological Effects of a New Indolinone Derivative in Experimental Pneumonitis in Rats. Bull Exp Biol Med 175, 459–462 (2023). https://doi.org/10.1007/s10517-023-05886-z

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  • DOI: https://doi.org/10.1007/s10517-023-05886-z

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