Skip to main content
SpringerLink
Log in

Molecular Hydrogen Reduces the Degree of Endothelial Alteration under Conditions of Chronic Heart Failure

  • GENERAL PATHOLOGY AND PATHOLOGICAL PHYSIOLOGY
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of molecular hydrogen H2 on the content of circulating endothelial cells and the macrohistological structure of the heart in rats with simulated chronic heart failure. Inhalation with 2% H2 was carried out repeatedly (40 min per day for 5 consecutive days) or once (40 min). Molecular hydrogen inhalations in both regimens caused a decrease in the number of circulating endothelial cells; the most pronounced effect was observed after repeated inhalations on day 14 after chronic heart failure modeling. The decrease in the count of circulating endothelial cells under the action of H2 was accompanied by recovery of the myocardial structure and a decrease in its weight. Molecular hydrogen in chronic heart failure limited the damage to endothelial cells and improved the structure of rat myocardium, which allows us to consider H2 inhalations as the means reducing the progression of chronic heart failure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Maliukova NG. Interrelation between lipid peroxidation and indices of hemocoagulation in patients with chronic heart failure resulted from ischemic heart disease. Lik. Sprava. 2007;(1-2):32-35.

    Google Scholar 

  2. Balistreri CR. Promising strategies for preserving adult endothelium health and reversing its dysfunction: from liquid biopsy to new omics technologies and noninvasive circulating biomarkers. Int. J. Mol. Sci. 2022;23(14):7548. doi: https://doi.org/10.3390/ijms23147548

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Prashchayeu KI, Ilnitski AN, Bessarabov VI, Pavlova TV, Kvetnaya TV, Bolhovitina OA, Pozdnyakova NM. Molecular basis of development and progression of heart failure in middle and old age. Mol. Med. 2012;(6):60-63. Russian.

  4. Coll B, Alonso-Villaverde C, Joven J. Monocyte chemoattractant protein-1 and atherosclerosis: is there room for an additional biomarker? Clin. Chim. Acta. 2007;383(1-2):21-29. doi: https://doi.org/10.1016/j.cca.2007.04.019

    Article  CAS  PubMed  Google Scholar 

  5. Mel’nikova YuS, Makarova TP. Endothelial dysfunction as the key link of chronic diseases pathogenesis. Kazan. Med. Zh. 2015;96(4):659-665. Russian. doi: https://doi.org/10.17750/KMJ2015-659

  6. Magdaliz TI. Disfunction of endothelium with chronic cardiac insufficiency and influence of inhibitors renin-angiotensin system. Vestn. Kharkov. Nats. Univ. Im. V.N.Karazina. Ser. Med. 2005;(10):81-85. Russian.

  7. Higashi Y, Noma K, Yoshizumi M, Kihara Y. Endothelial function and oxidative stress in cardiovascular diseases. Circ. J. 2009;73(3):411-418. doi: https://doi.org/10.1253/circj.cj-08-1102

    Article  CAS  PubMed  Google Scholar 

  8. Ning Y, Shang Y, Huang H, Zhang J, Dong Y, Xu W, Li Q. Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats. PLoS One. 2013;8(12):e83429. doi: https://doi.org/10.1371/journal.pone.0083429

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Deryugina AV, Danilova DA, Skokova AA, Brichkin YuD, Pichugin VV, Medvedev AP, Ryazanov MV, Fedorov SA. Dynamics of metabolic and oxidative parameters of erythrocytes during treatment of chronic heart failure with molecular hydrogen. Bull. Exp. Biol. Med. 2022;173(5):602-605. doi: https://doi.org/10.1007/s10517-022-05595-z

  10. Kiseleva NI. Endothelial cells circulating in blood as a marker of endothelial dysfunction in pregnancy complicated by gestosis. Vestn. Vitebsk. Gos. Med. Univ. 2007;6(1):119-125. Russian.

  11. Statkevich TV, Mitkovskaya NP, Balysh AM, Rambalskaya AR, Petrova KB, Moklaya AV, Levkovich IE. Pulmonary embolism in the presence of chronic heart failure syndrome: a structural-functional state of the cardiovascular system. Sib. Med. Zh. (Tomsk). 2020;35(2):114-122. Russian. doi: https://doi.org/10.29001/2073-8552-2020-35-2-114-122

  12. Brenchagov AV, Zamotaeva MN, Luzina EA, Zaitseva EN, Pizhamova VV. The study of new cytoprotectors in rat model of chronic heart failure. Ross. Kardiol. Zh. 2020;25(S2):39-40. Russian.

  13. Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, Pearl EJ, Petersen OH, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, Würbel H. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PLoS Biol. 2020;18(7):e3000410. doi: https://doi.org/10.1371/journal.pbio.3000410

  14. Petrishchev NN, Berkevich OA, Vlasov TD, Volkova EV, Zueva EE, Mozgovaya EV. Diagnostic value of detection of desquamated endothelial cells in the blood. Klin. Lab. Diagnost. 2001;(1):50-52. Russian.

  15. Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q, Zhu Y, Wang X, Schmidt K, de Wit C, Erdmann J, Schunkert H, Aherrahrou Z, Kong W. ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1. Circulation. 2015;131(13):1191-1201. doi: https://doi.org/10.1161/CIRCULATIONAHA.114.014072

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. N. I. Lobachevsky National Research State University of Nizhny Novgorod, Nizhny Novgorod, Russia

    A. V. Deryugina & D. A. Danilova

Authors
  1. A. V. Deryugina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. A. Danilova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. A. Danilova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 4, pp. 426-429, April, 2023

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Deryugina, A.V., Danilova, D.A. Molecular Hydrogen Reduces the Degree of Endothelial Alteration under Conditions of Chronic Heart Failure. Bull Exp Biol Med 175, 433–436 (2023). https://doi.org/10.1007/s10517-023-05880-5

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-023-05880-5

Keywords

Search

Navigation