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On the Correlations of Gray Matter with Schizotypy in Mentally Healthy Subjects

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We analyzed the relationships between morphometric characteristics of brain gray matter and schizotypy. Mentally healthy subjects (n=164, age 18-35 years) completed Russian version of SPQ-74 test and underwent high-field 3T MRI. Cortical thickness in the right frontal pole (determined with FreeSurfer 6.0.0) positively correlated with negative schizotypy factor. The revealed features can reflect the protective mechanisms (resilience) against the development of mental disorders and also can be a result of individual ontogenesis trajectories manifested in deceleration of the decrease of the cortex thickness during first 3 decades of life.

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Authors and Affiliations

  1. Scientific Center of Mental Health, Moscow, Russia

    I. S. Lebedeva & A. S. Tomyshev

  2. National Research University Higher School of Economics (HSE University), Moscow, Russia

    E. V. Pechenkova

Authors
  1. I. S. Lebedeva
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  2. A. S. Tomyshev
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  3. E. V. Pechenkova
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Correspondence to I. S. Lebedeva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 2, pp. 261-264, February, 2023

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Lebedeva, I.S., Tomyshev, A.S. & Pechenkova, E.V. On the Correlations of Gray Matter with Schizotypy in Mentally Healthy Subjects. Bull Exp Biol Med 175, 291–294 (2023). https://doi.org/10.1007/s10517-023-05852-9

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  • DOI: https://doi.org/10.1007/s10517-023-05852-9

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