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The Level of Anti-Polyethylene Glycol (PEG) Immunoglobulin G Antibodies in Human Serum Does Not Correlate with Efficiency of PEGylated Nanoparticle Uptake by Monocytes

  • BIOTECHNOLOGIES
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Bulletin of Experimental Biology and Medicine Aims and scope

The presence of anti-polyethylene glycol (PEG) antibodies can limit the clinical efficacy of PEGylated drugs and cause anaphylactic reactions in patients. Monocytes/macrophages are effector cells involved in IgG-mediated passive systemic anaphylaxis. We studied the influence of human blood serum on the efficiency of uptake of PEGylated nanoparticles by human blood monocytes. It has been shown that magnetic nanoparticles modified with PEG-3000 and solid lipid nanoparticles containing PEG-2000 are avidly internalized by human blood monocytes in vitro, the uptake efficiency depends on the features (composition) of donor blood serum, but does not correlate with the level of the IgG antibody against PEG.

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Authors and Affiliations

  1. Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    K. V. Nevskaya, S. V. Krivoshchekov, A. P. Zima, A. N. Baikov, A. M. Gur’ev & A. G. Pershina

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  1. K. V. Nevskaya
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  2. S. V. Krivoshchekov
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  3. A. P. Zima
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  4. A. N. Baikov
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  5. A. M. Gur’ev
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  6. A. G. Pershina
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Corresponding author

Correspondence to A. G. Pershina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 2, pp. 239-243, February, 2023

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Nevskaya, K.V., Krivoshchekov, S.V., Zima, A.P. et al. The Level of Anti-Polyethylene Glycol (PEG) Immunoglobulin G Antibodies in Human Serum Does Not Correlate with Efficiency of PEGylated Nanoparticle Uptake by Monocytes. Bull Exp Biol Med 175, 270–274 (2023). https://doi.org/10.1007/s10517-023-05848-5

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  • DOI: https://doi.org/10.1007/s10517-023-05848-5

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