Skip to main content
SpringerLink
Log in

Protective Effect of a New Monophenolic Antioxidant TS-13 in a Mouse Model of Parkinson’s Disease

  • EXPERIMENTAL METHODS FOR CLINICAL PRACTICE
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The development of means of the prevention and treatment of age-related neurodegenerative diseases, as well as geroprotectors, among other things, is based on the inflammatory and free radical theories of aging. In this context, we studied the effect of sodium monophenol 3-(3’-tert-butyl-4’-hydroxyphenyl)propyl thiosulfonate (TS-13) on the behavioral and locomotor activity of C57BL/6 mice in modeling Parkinson’s disease by MPTP neurotoxin injection. TS-13 administration significantly improved orientation and exploratory activity and emotional response of the animals in the open field test, but did not affect the increase in anxiety caused by MPTP injection. Long-term (6 months) TS-13 administration did not suppress spontaneous motor activity in BALB/c mice and slightly increased their exploratory activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Rogaev EI. Different pathways to neurodegeneration. Biochemistry. 2018;83(9):1007-1008. doi: https://doi.org/10.1134/S0006297918090018

    Article  CAS  PubMed  Google Scholar 

  2. Shields HJ, Traa A, Van Raamsdonk JM. Beneficial and detrimental effects of reactive oxygen species on lifespan: a comprehensive review of comparative and experimental studies. Front. Cell Dev. Biol. 2021;9:628157. doi: https://doi.org/10.3389/fcell.2021.628157

  3. Lee J, Kim HJ. Normal aging induces changes in the brain and neurodegeneration progress: review of the structural, biochemical, metabolic, cellular, and molecular changes. Front. Aging Neurosci. 2022;14:931536. doi: https://doi.org/10.3389/fnagi.2022.931536

  4. Zenkov NK, Kozhin PM, Chechushkov AV, Kandalintseva NV, Martinovich GG, Menshchikova EB. Oxidative stress in aging. Uspekhi Gerontol. 2020;33(1):10-22. Russian. doi: https://doi.org/10.34922/AE.2020.33.1.001

  5. Cobley JN, Fiorello ML, Bailey DM. 13 reasons why the brain is susceptible to oxidative stress. Redox Biol. 2018;15:490-503. doi: https://doi.org/10.1016/j.redox.2018.01.008

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Tebay LE, Robertson H, Durant ST, Vitale SR, Penning TM, Dinkova-Kostova AT, Hayes JD. Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. Free Radic. Biol. Med. 2015;88(Pt B):108-146. doi: https://doi.org/10.1016/j.freeradbiomed.2015.06.021

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Merelli A, Repetto M, Lazarowski A, Auzmendi J. Hypoxia, Oxidative Stress, and Inflammation: Three Faces of Neurodegenerative Diseases. J. Alzheimers Dis. 2021;82(S 1):S109-S126. doi: https://doi.org/10.3233/JAD-201074

  8. Rivas F, Poblete-Aro C, Pando ME, Allel MJ, Fernandez V, Soto A, Nova P, Garcia-Diaz D. Effects of polyphenols in aging and neurodegeneration associated with oxidative stress. Curr. Med. Chem. 2022;29(6):1045-1060. doi: https://doi.org/10.2174/0929867328666211101100632

    Article  CAS  PubMed  Google Scholar 

  9. Rahman MM, Rahaman MS, Islam MR, Rahman F, Mithi FM, Alqahtani T, Almikhlafi MA, Alghamdi SQ, Alruwaili AS, Hossain MS, Ahmed M, Das R, Emran TB, Uddin MS. Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects. Molecules. 2021;27(1):233. doi: https://doi.org/10.3390/molecules27010233

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Menshchikova E, Tkachev V, Lemza A, Sharkova T, Kandalintseva N, Vavilin V, Safronova O, Zenkov N. Water-soluble phenol TS-13 combats acute but not chronic inflammation. Inflamm. Res. 2014;63(9):729-740. doi: https://doi.org/10.1007/s00011-014-0746-0

    Article  CAS  PubMed  Google Scholar 

  11. Komleva Y, Chernykh A, Lopatina O, Gorina Y, Lokteva I, Salmina A, Gollasch M. Inflamm-Aging and Brain Insulin Resistance: New Insights and Role of Life-style Strategies on Cognitive and Social Determinants in Aging and Neurodegeneration. Front. Neurosci. 2021;14:618395. doi: https://doi.org/10.3389/fnins.2020.618395

  12. Gaynutdinov PI, Kozhin PM, Chechushkov AV, Martinovich GG, Kholshin SV, Kandalintseva NV, Zenkov NK, Menshchikova EB. Inverse relationship between the antioxidant activity of structurally related synthetic monophenols and their toxicity in tumor cells. Sib. Nauch. Med. Zh. 2018;38(1):22-31. Russian. doi: https://doi.org/10.15372/SSMJ20180104

  13. Bakhtiyarova ShK, Kapysheva UN, Ablaykhanova NT, Baimbetova AK, Zhaksymov BI, Korganbaeva AA, Ydyrys A, Bolatkhan MB, Dautova MB. Behavior of animals in various tests. Mezhdunar. Zh. Priklad. Fundam. Issled. 2017;(8-1):92-96. Russian.

  14. Sudakov SK, Nazarova GA, Alekseeva EV, Bashkatova VG. Estimation of the level of anxiety in rats: differences in results of open-field test, elevated plus-maze test, and Vogel’s conflict test. Bull. Exp. Biol. Med. 2013;155(3):295-297. doi: https://doi.org/10.1007/s10517-013-2136-y

    Article  CAS  PubMed  Google Scholar 

  15. Shoji H, Miyakawa T. Effects of test experience, closed-arm wall color, and illumination level on behavior and plasma corticosterone response in an elevated plus maze in male C57BL/6J mice: a challenge against conventional interpretation of the test. Mol. Brain. 2021;14(1):34. doi: https://doi.org/10.1186/s13041-020-00721-2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Federal Research Center of Fundamental and Translational Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    E. B. Menshchikova, M. V. Khrapova, P. M. Kozhin, A. V. Chechushkov, A. E. Serykh & L. P. Romakh

  2. Novosibirsk State Pedagogical University, Novosibirsk, Russia

    N. V. Kandalintseva

Authors
  1. E. B. Menshchikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. V. Khrapova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. M. Kozhin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. V. Chechushkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. E. Serykh
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. L. P. Romakh
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. N. V. Kandalintseva
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. B. Menshchikova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 2, pp. 233-238, February, 2023

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Menshchikova, E.B., Khrapova, M.V., Kozhin, P.M. et al. Protective Effect of a New Monophenolic Antioxidant TS-13 in a Mouse Model of Parkinson’s Disease. Bull Exp Biol Med 175, 265–269 (2023). https://doi.org/10.1007/s10517-023-05847-6

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-023-05847-6

Keywords

Search

Navigation