We studied the effects of the extract of the terrestrial part of Aconitum baicalense in BALB/c female mice at the early stages after the injection of N-methyl-N-nitrosourea (MNU). The extract reduced inflammatory activity and tumor growth in the mammary gland. The antitumor and anti-inflammatory effects of the extract are based on the inhibition of cancer stem cells, hematopoietic stem cells, and hematopoietic progenitor cells that promote inflammation. The extract of A. baicalense disrupted the recruitment of epithelial progenitor cells and angiogenesis precursors to the mammary gland preventing neovascularization and transformation of epithelial cells into tumor cells.
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Agnoletto C, Corrà F, Minotti L, Baldassari F, Crudele F, Cook WJJ, Di Leva G, d’Adamo AP, Gasparini P, Volinia S. Heterogeneity in circulating tumor cells: the relevance of the stem-cell subset. Cancers (Basel). 2019;11(4):483. doi: https://doi.org/10.3390/cancers11040483
Vinuesa-Pitarch E, Ortega-Álvarez D, Rodilla V. How lineage tracing studies can unveil tumor heterogeneity in breast cancer. Biomedicines. 2021;10(1):3. doi: https://doi.org/10.3390/biomedicines10010003
Ermakova NN, Pershina OV, Zhukova MA, Pakhomova AV, Pan ES, Sandrikina LA, Krupin VA, Rybalkina OYu, Dygai AM, Skurikhin EG. Early diagnostic markers and therapeutic targets for experimental breast cancer. Bull. Exp. Biol. Med. 2021;172(6):747-751. doi: https://doi.org/10.1007/s10517-022-05470-x
Dygai AM, Skurikhin EG, Pershina OV, Ermakova NN, Krupin VA, Ermolaeva LA, Stakheeva MN, Choinzonov EL, Goldberg VE, Reikhart DV, Ellinidi VN, Kravtsov VYu. Role of hematopoietic stem cells in inflammation of the pancreas during diabetes mellitus. Bull. Exp. Biol. Med. 2016;160(4):474-479. doi: https://doi.org/10.1007/s10517-016-3200-1
Jeong YJ, Oh HK, Park SH, Bong JG. Association between inflammation and cancer stem cell phenotype in breast cancer. Oncol. Lett. 2018;15(2):2380-2386. doi: https://doi.org/10.3892/ol.2017.7607
Wangchuk P, Navarro S, Shepherd C, Keller PA, Pyne SG, Loukas A. Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis. Sci. Rep. 2015;5:12845. doi: https://doi.org/10.1038/srep12845
El-Shazly M, Tai CJ, Wu TY, Csupor D, Hohmann J, Chang FR, Wu YC. Use, history, and liquid chromatography/mass spectrometry chemical analysis of Aconitum. J. Food Drug Anal. 2016;24(1):29-45. doi: https://doi.org/10.1016/j.jfda.2015.09.001
Pashinskii VG, Gaidamovich NN, Povet’eva TN, Vetoshkina TV, Nesterova UV, Pushkarskii SV. The influence of aconitum preparations on the development of chronic inflammation. Eksper. Klin. Farmakol. 2006;69(2):55-57. Russian.
Pushkarskiy SV, Pashinskiy VG, Povetyeva TN, Nesterova UV, Gaydamovich NN, Semyonov AA, Zhapova Ts, Pogodaeva NN. Stress-modulation effect of Aconitum baicalense (Ranunculaceae) alkaloids on the background of inflammation and immobilization. Rast. Res. 2006;42(2):116-119. Russian.
Tsubura A, Lai YC, Miki H, Sasaki T, Uehara N, Yuri T, Yoshizawa K. Review: Animal models of N-Methyl-N-nitrosourea-induced mammary cancer and retinal degeneration with special emphasis on therapeutic trials. In Vivo. 2011;25(1):11-22.
Faustino-Rocha AI, Ferreira R, Oliveira PA, Gama A, Ginja M. N-Methyl-N-nitrosourea as a mammary carcinogenic agent. Tumour Biol. 2015;36(12):9095-9117. doi: https://doi.org/10.1007/s13277-015-3973-2
Cui P, Han H, Wang R, Yang L. Identification and determination of Aconitum alkaloids in Aconitum herbs and Xiaohuoluo pill using UPLC-ESI-MS. Molecules. 2012;17(9):10 242-10 257. doi: https://doi.org/10.3390/molecules170910242
Caiado F, Pietras EM, Manz MG. Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection. J. Exp. Med. 2021;218(7):e20201541. doi: https://doi.org/10.1084/jem.20201541
Keller PJ, Lin AF, Arendt LM, Klebba I, Jones AD, Rudnick JA, DiMeo TA, Gilmore H, Jefferson DM, Graham RA, Naber SP, Schnitt S., Kuperwasser C. Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines. Breast Cancer Res. 2010;12(5):R87. doi: https://doi.org/10.1186/bcr2755
Danova M, Comolli G, Manzoni M, Torchio M, Mazzini G. Flow cytometric analysis of circulating endothelial cells and endothelial progenitors for clinical purposes in oncology: A critical evaluation. Mol. Clin. Oncol. 2016;4(6):909-917. doi: https://doi.org/10.3892/mco.2016.823
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 2, pp. 220-226, February, 2023
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Pershina, O.V., Ermakova, N.N., Pakhomova, A.V. et al. The Role of Cancer and Somatic Stem Cells in the Anti-Inflammatory and Antitumor Effects of Aconitum baicalense Extract on Experimental Breast Cancer. Bull Exp Biol Med 175, 254–259 (2023). https://doi.org/10.1007/s10517-023-05845-8
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DOI: https://doi.org/10.1007/s10517-023-05845-8