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Comparative Analysis of Stress-Protective Activity and Prevention of Fatigue during Physical Load of Standardized Humic Acids from Peat and Officinal Preparations of Succinic Acid in Experiment

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The effect of humic acids and substances with similar action — derivatives of succinic acid (ethylmethylhydroxypyridine succinate) and combined agent consisting of succinic acid, nicotinamide, riboflavin, and riboxin on the performance and stress resistance of experimental rats was studied. Performance was assessed in the test of exhaustive forced swimming with a load, stress resistance was evaluated by the serum level of corticosterone and open field behavior, and the state of anaerobic metabolism was estimated by the serum level of lactate after swimming test. Humic acids from peat showed anti-stress activity comparable to that of the officinal preparation and preventive effect on fatigue during physical exercise. They can be recommended as a component for the development of drugs that increase human performance and stress resistance.

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Authors and Affiliations

  1. Federal Research Clinical Center of Medical Rehabilitation and Balneology, Federal Medical-Biological Agency, Moscow, Russia

    T. A. Zamoshchina, A. A. Gostyukhina, A. V. Prokopova, K. V. Zaitsev & M. V. Svetlik

  2. Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    T. A. Zamoshchina, M. V. Zykova, L. A. Logvinova, M. V. Svetlik & M. V. Belousov

  3. National Research Tomsk State University, Tomsk, Russia

    T. A. Zamoshchina, A. A. Gostyukhina, A. V. Prokopova & M. V. Svetlik

  4. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    A. M. Dygai

Authors
  1. T. A. Zamoshchina
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  2. A. A. Gostyukhina
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  3. M. V. Zykova
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  4. L. A. Logvinova
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  5. A. V. Prokopova
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  6. K. V. Zaitsev
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  7. M. V. Svetlik
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  8. M. V. Belousov
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  9. A. M. Dygai
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Corresponding author

Correspondence to A. A. Gostyukhina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 2, pp. 171-176, February, 2023

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Zamoshchina, T.A., Gostyukhina, A.A., Zykova, M.V. et al. Comparative Analysis of Stress-Protective Activity and Prevention of Fatigue during Physical Load of Standardized Humic Acids from Peat and Officinal Preparations of Succinic Acid in Experiment. Bull Exp Biol Med 175, 210–214 (2023). https://doi.org/10.1007/s10517-023-05836-9

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  • DOI: https://doi.org/10.1007/s10517-023-05836-9

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