Skip to main content
SpringerLink
Log in

Possible Kidney Complications after Application of Cell Technologies for the Repair of the Resected Liver

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

  • 1 Altmetric

The state of rat kidneys after injection of bone marrow multipotent stromal cells (MSC) labeled with Vybrant CM-Dil into intact or resected liver was studied by fluorescence microscopy. The main structural changes in the kidneys after MSC injection into intact and partially resected liver manifested as granular dystrophy and necrobiotic/necrotic changes in single epithelial cells of the distal tubules and collecting ducts, thrombosis of some vessels, progression of an ascending urinary tract infection (detection of dust-like fluorescent objects), which can be due to the immunomodulating or even immunosuppressive influence of MSC and their detritus. MSC injected into the intact or resected liver, as well as the products of their degradation were not detected in the kidneys at all terms of observation. After injection of MSC into partially resected liver, manifestations of bacterial contamination of the renal medulla appeared later. The injection of MSC into the liver can be complicated by thrombosis of the renal vessels, which should be taken into account when using this administration route in the cell therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Galipeau J, Sensébé L. Mesenchymal stromal cells: clinical challenges and therapeutic opportunities. Cell Stem Cell. 2018;22(6):824-833. doi: https://doi.org/10.1016/j.stem.2018.05.004

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Naji A, Eitoku M, Favier B, Deschaseaux F, Rouas-Freiss N, Suganuma N. Biological functions of mesenchymal stem cells and clinical implications. Cell. Mol. Life Sci. 2019;76(17):3323-3348. doi: https://doi.org/10.1007/s00018-019-03125-1

    Article  CAS  PubMed  Google Scholar 

  3. Wang H, Thorling C.A, Xu ZP, Crawford DHG, Liang X, Liu X, Roberts MS. Visualization and modeling of the in vivo distribution of mesenchymal stem cells. Curr. Protoc. Stem Cell Biol. 2017;43:2B.8.1-2B.8.17. doi: https://doi.org/10.1002/cpsc.39

  4. Konieva AA, Kholodenko IV, Shragina OA, Kholodenko RV, Burunova VV, Bibaeva LV, Yarygin KN, Yarygin VN. Functional properties of mesenchymal stem cells labeled with magnetic microparticles in vitro and analysis of their distribution after transplantation. Bull. Exp. Biol. Med. 2010;150(1):131-136. doi: https://doi.org/10.1007/s10517-010-1087-9.

    Article  CAS  PubMed  Google Scholar 

  5. Maiborodin IV, Maslov RV, Mikheeva TV, Khomenyuk SV, Maiborodina VI, Morozov VV, Ryaguzov ME, Marchukov SV, Kozlova JuN. The distribution of multipotent mesenchymal stromal cells and their detritus throughout the organism after subcutaneous introduction. Zh. Obshch. Biol. 2020;81(2):96-107. Russian. doi: https://doi.org/10.31857/S0044459620020050

  6. Tan X, Gong YZ, Wu P, Liao DF, Zheng XL. Mesenchymal stem cell-derived microparticles: a promising therapeutic strategy. Int. J. Mol. Sci. 2014;(8):14 348-14 363. doi: https://doi.org/10.3390/ijms150814348

  7. Maiborodin IV, Maslov RV, Mikheeva TV, Elovskiy AA, Figurenko NF, Maiborodina VI, Shevela AI, Anishchenko VV. Macrophagal adsorption of multipotent mesenchymal stromal cells and their debris from vascular bed proves the migration of these cellular elements through the vessels after tissue injection. Mol. Med. 2018;16(4):56-61. Russian. doi: https://doi.org/10.29296/24999490-2018-04-10

  8. Camp DM, Loeffler DA, Farrah DM, Borneman JN, LeWitt PA. Cellular immune response to intrastriatally implanted allogeneic bone marrow stromal cells in a rat model of Parkinson’s disease. J. Neuroinflammation. 2009;6:17. doi: https://doi.org/10.1186/1742-2094-6-17

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Huang Y, Wu Q, Tam PKH. Immunomodulatory mechanisms of mesenchymal stem cells and their potential clinical applications. Int. J. Mol. Sci. 2022;23(17):10023. doi: https://doi.org/10.3390/ijms231710023

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Weiss ARR, Dahlke MH. Immunomodulation by Mesenchymal Stem Cells (MSC): Mechanisms of action of living, apoptotic, and dead MSC. Front. Immunol. 2019;10:1191. doi: https://doi.org/10.3389/fimmu.2019.01191

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Maiborodin IV, Figurenko NF, Elovskiy AA, Mikheeva TV, Maslov RV, Maiborodina VI, Shevela AI. Possibility of inflammatory injures development in intact liver after the multipotent stromal cell injection in experiment. Novosti Khirurgii. 2019;27(1):5-15. Russian. doi: https://doi.org/10.18484/2305-0047.2019.1.5

  12. Maiborodin I, Lushnikova E, Klinnikova M, Klochkova S. Some special aspects of liver repair after resection and administration of multipotent stromal cells in experiment. Life (Basel). 2021. 11(1):66. doi: https://doi.org/10.3390/life11010066

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Kiselevskii MV, Vlasenko RY, Stepanyan NG, Shubina IZ, Sitdikova SM, Kirgizov KI, Varfolomeeva SR. Secretome of Mesenchymal Bone Marrow Stem Cells: Is It Immunosuppressive or Proinflammatory? Bull. Exp. Biol. Med. 2021;172(2):250-253. doi: https://doi.org/10.1007/s10517-021-05371-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Moskaleva EY, Semochkina YP, Shuvatova VG, Rodina AV, Krasheninnikova AA. Mesenchymal Stem Cells from Mouse Adipose Tissue Stimulate Tumor Growth. Bull. Exp. Biol. Med. 2019;167(1):145-149. doi: https://doi.org/10.1007/s10517-019-04479-z

    Article  PubMed  Google Scholar 

  15. Takasaki Y, Watanabe M, Yukawa H, Sabarudin A, Inagaki K, Kaji N, Okamoto Y, Tokeshi M, Miyamoto Y, Noguchi H, Umemura T, Hayashi S, Baba Y, Haraguchi H. Estimation of the distribution of intravenously injected adipose tissue-derived stem cells labeled with quantum dots in mice organs through the determination of their metallic components by ICPMS. Anal. Chem. 2011;83(21):8252-8258. doi: https://doi.org/10.1021/ac202053y

    Article  CAS  PubMed  Google Scholar 

  16. Lei Y, Tang H, Yao L, Yu R, Feng M, Zou B. Applications of mesenchymal stem cells labeled with Tat peptide conjugated quantum dots to cell tracking in mouse body. Bioconjug. Chem. 2008. 19(2):421-427. doi: https://doi.org/10.1021/bc0700685

    Article  CAS  PubMed  Google Scholar 

  17. Baird FJ, Wadsworth MP, Hill JE. Evaluation and optimization of multiple fluorophore analysis of a Pseudomonas aeruginosa biofilm. J. Microbiol. Methods. 2012;90(3):192-196. doi: https://doi.org/10.1016/j.mimet.2012.05.004

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Song N, Scholtemeijer M, Shah K. Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential. Trends Pharmacol. Sci. 2020;41(9):653-664. doi: https://doi.org/10.1016/j.tips.2020.06.009

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Kugeratski FG, Kalluri R. Exosomes as mediators of immune regulation and immunotherapy in cancer. FEBS J. 2021;288(1):10-35. doi: https://doi.org/10.1111/febs.15558

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia

    I. V. Maiborodin, R. V. Maslov, S. V. Marchukov, B. V. Sheplev, V. I. Maiborodina & E. L. Lushnikova

  2. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    I. V. Maiborodin & M. E. Ryaguzov

  3. Department of Human Anatomy, Institute of Medicine, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia

    S. V. Klochkova

Authors
  1. I. V. Maiborodin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. V. Maslov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. V. Marchukov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. V. Klochkova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. B. V. Sheplev
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V. I. Maiborodina
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M. E. Ryaguzov
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. E. L. Lushnikova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I. V. Maiborodin.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 27-33, March, 2023

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Maiborodin, I.V., Maslov, R.V., Marchukov, S.V. et al. Possible Kidney Complications after Application of Cell Technologies for the Repair of the Resected Liver. Bull Exp Biol Med 175, 138–143 (2023). https://doi.org/10.1007/s10517-023-05825-y

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-023-05825-y

Keywords

Search

Navigation