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Application of Behavioral Tests for Evaluation of an Experimental Model of Alzheimer’s Disease in Female Rats

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Bulletin of Experimental Biology and Medicine Aims and scope

Alzheimer’s disease was modeled in female Wistar rats aged 4 months by stereotaxic bilateral injection of a synthetic peptide β-amyloid (Aβ1-42) into the hippocampus. Behavioral tests (open field, Y-maze, passive avoidance, and Morris water maze) revealed significant impairment of memory and spatial navigation 8 weeks after β-amyloid administration. At this term, the cognitive impairments typical of Alzheimer’s disease are reproduced. The experimental model of Alzheimer’s disease proposed by us can be used in preclinical studies of drugs for the treatment of this pathology.

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Authors and Affiliations

  1. V. P. Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia

    E. K. Karsuntseva, A. D. Voronova, A. V. Chadin, V. V. Shishkina, G. A. Fursa, S. S. Andretsova, O. V. Stepanova & V. P. Chekhonin

  2. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    G. A. Fursa & V. P. Chekhonin

  3. M. V. Lomonosov Moscow State University, Moscow, Russia

    S. S. Andretsova

  4. University Clinical Hospital No. 1, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

    I. V. Reshetov

  5. E. I. Chazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia

    O. V. Stepanova

Authors
  1. E. K. Karsuntseva
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  2. A. D. Voronova
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  3. A. V. Chadin
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  4. V. V. Shishkina
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  5. G. A. Fursa
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  6. S. S. Andretsova
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  7. I. V. Reshetov
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  8. O. V. Stepanova
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  9. V. P. Chekhonin
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Correspondence to E. K. Karsuntseva.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 14-19, March, 2023

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Karsuntseva, E.K., Voronova, A.D., Chadin, A.V. et al. Application of Behavioral Tests for Evaluation of an Experimental Model of Alzheimer’s Disease in Female Rats. Bull Exp Biol Med 175, 126–131 (2023). https://doi.org/10.1007/s10517-023-05823-0

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