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Therapeutic Efficacy and Migration of Mesenchymal Stem Cells after Intracerebral Transplantation in Rats with Experimental Ischemic Stroke

  • CELL TECHNOLOGIES IN BIOLOGY AND MEDICINECELL MEDICINE
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied therapeutic efficacy and migration characteristics of mesenchymal stem cells isolated from the human placenta after their intracerebral (stereotactic) administration to rats with the experimental ischemic stroke. It was shown that cell therapy significantly improved animal survival rate and reduced the severity of neurological deficit. New data on the migration pathways of transplanted cells in the brain were obtained.

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Authors and Affiliations

  1. Federal Center of Brain Research and Neurotechnologies, Federal Medical-Biological Agency of Russia, Moscow, Russia

    D. D. Namestnikova, I. L. Gubskiy, E. A. Cherkashova & L. V. Gubsky

  2. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    D. D. Namestnikova, I. L. Gubskiy, E. A. Cherkashova, V. V. Kurilo, V. P. Chekhonin & L. V. Gubsky

  3. V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia

    K. K. Sukhinich & K. N. Yarygin

  4. V. P. Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia

    P. A. Melnikov & V. P. Chekhonin

  5. National Research Technology University “MISiS”, Moscow, Russia

    A. N. Gabashvili

  6. Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation, Moscow, Russia

    K. N. Yarygin

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  1. D. D. Namestnikova
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  2. I. L. Gubskiy
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  9. L. V. Gubsky
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Correspondence to I. L. Gubskiy.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 3-13, March, 2023

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Namestnikova, D.D., Gubskiy, I.L., Cherkashova, E.A. et al. Therapeutic Efficacy and Migration of Mesenchymal Stem Cells after Intracerebral Transplantation in Rats with Experimental Ischemic Stroke. Bull Exp Biol Med 175, 116–125 (2023). https://doi.org/10.1007/s10517-023-05822-1

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