Skip to main content
SpringerLink
Log in

Cytokine Profile and Concentrations of Metabolic Hormones in the Blood of Overweight Men with Coronary Arteriosclerosis

  • EXPERIMENTAL METHODS FOR CLINICAL PRACTICE
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Plasma concentrations of cytokines and metabolic hormones and their association with vulnerable atherosclerotic plaques were studied in 36 overweight men (age 40-77 years; BMI 25.0-29.9 kg/m2) with coronary atherosclerosis who underwent coronary endarterectomy. According to histological analysis, the patients were divided into two groups: with stable (17 (47.2%) men) and vulnerable (19 (52.8%) men) plaques in the coronary arteries. The plasma levels of cytokines and metabolic hormones were measured by multiplex analysis: C-peptide, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1, glucagon, IL-6, insulin, leptin, monocyte chemoattractant protein-1, and TNFα. In overweight patients with vulnerable plaques, the level of glucagon was lower by 4.17 times, GIP — by 2.47 times, and insulin — by 2.1 times. At the same time, the risk of occurrence of a vulnerable plaque increases by 5.4% with a decrease in GIP concentration by 1 pg/ml irrespectively of age, as well as by 3.1% with an increase in insulin concentration by 10 pg/ml, without achieving statistical significance when included in the age model. Overweight men with coronary atherosclerosis and vulnerable plaques have lower levels of insulin, glucagon, and GIP. The levels of GIP and insulin are inversely associated with the risk of having vulnerable atherosclerotic plaque.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384:766-781. doi: https://doi.org/10.1016/S0140-6736(14)60460-8

  2. Martinchik AN, Laikam KE, Kozyreva NA, Keshabyants EE, Mikhailov NA, Baturin AK, Smirnova EA. The prevalence of obesity in various socio-demographic groups of the population of Russia. Voprosy. Pitaniya. 2021;90(3):67-76. Russian. doi: https://doi.org/10.33029/0042-8833-2021-90-3-67-76

  3. Russian Society of Cardiology (RSC). 2020 Clinical practice guidelines for stable coronary artery disease. Ross. Kardiol. Zh. 2020;25(11):201-250. Russian. doi: https://doi.org/10.15829/1560-4071-2020-4076

  4. GBD 2015 Obesity Collaborators. Health Effects of Overweight and Obesity in 195 Countries over 25 Years. N. Engl. J. Med. 2017;377(1):13-27. doi: https://doi.org/10.1056/NEJMoa1614362

  5. Kologrivova IV, Vinnitskaya IV, Koshelskaya OA, Suslova TE. Visceral obesity and cardiometabolic risk: features of hormonal and immune regulation. Ozhirenie Metabolizm. 2017;14(3):3-10. Russian. doi: https://doi.org/10.14341/omet201733-10

  6. The Vulnerable Plaque. Waksman R, Serruys PW, Schaar J, eds. London, 2007.

  7. Dedov II, Mokrysheva NG, Mel’nichenko GA, Troshina EA, Mazurina NV, Ershova EV, Komshilova KA, Andreeva EN, Antsiferov MB, Biriukova EV, Bordan NS, Vagapova GR, Volkova AR, Volkova NI, Volynkina AP, Dzgoeva FKh, Kiseleva TP, Neimark AE, Romantsova TI, Ruiatkina LA, Suplotova LA, Khalimov YuSh, Yashkov YuI. Obesity. Clinical guidelines. Consilium Medicum. 2021;23(4):311-325. Russian. doi: https://doi.org/10.26442/20751753.2021.4.200832

  8. Eurasian association of cardiology (EAC)/Russian national atherosclerosis society (RNAS, Russia) guidelines for the diagnosis and correction of dyslipidemia for the prevention and treatment of atherosclerosis (2020). Evraz. Kardiol. Zh. 2020;(2):6-29. Russian. doi: https://doi.org/10.38109/2225-1685-2020-2-6-29

  9. Osaka N, Kushima H, Mori Y, Saito T, Hiromura M, Tera-saki M, Yashima H, Ohara M, Fukui T, Matsui T, Hirano T, Yamagishi SI. Anti-inflammatory and atheroprotective properties of glucagon. Diab. Vasc. Dis. Res. 2020;17(5): 1479164120965183. doi: https://doi.org/10.1177/1479164120965183

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Tsygankova OV, Veretyuk VV, Ametov AS. Incretins today: multiple effects and therapeutic potential. Sakhar. Diabet. 2019;22(1):70-78. Russian. doi: https://doi.org/10.14341/DM9841

  11. Berglund LM, Lyssenko V, Ladenvall C, Kotova O, Edsfeldt A, Pilgaard K, Alkayyali S, Brøns C, Forsblom C, Jonsson A, Zetterqvist AV, Nitulescu M, McDavitt CR, Dunér P, Stancáková A, Kuusisto J, Ahlqvist E, Lajer M, Tarnow L, Madsbad S, Rossing P, Kieffer TJ, Melander O, Orho-Melander M, Nilsson P, Groop PH, Vaag A, Lindblad B, Gottsäter A, Laakso M, Goncalves I, Groop L, Gomez MF. Glucose-dependent insulinotropic polypeptide stimulates osteopontin expression in the vasculature via endothelin-1 and CREB. Diabetes. 2016;65(1):239-254. doi: https://doi.org/10.2337/db15-0122

    Article  CAS  PubMed  Google Scholar 

  12. Nagashima M, Watanabe T, Terasaki M, Tomoyasu M, Nohtomi K, Kim-Kaneyama J, Miyazaki A, Hirano T. Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice. Diabetologia. 2011;54(10):2649-2659. doi: https://doi.org/10.1007/s00125-011-2241-2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Smetnev SA, Meshkov AN. The role of peptide hormones (adiponectin, leptin, insulin) in the pathogenesis of atherosclerosis. Rats. Farmakoter. Kardiol. 2015;11(5):522-528. Russian. doi: https://doi.org/10.20996/1819-6446-2015-11-5-522-528

  14. Metelskaya VA, Zhatkina MV, Gavrilova NE, Yarovaya EB, Bogdanova NL, Kutsenko VA, Rudenko BA, Drapkina OM. Associations of circulating biomarkers with the presence and severity of coronary, carotid and femoral arterial atherosclerosis. Kardiovaskular. Ter. Prof. 2021;20(8):37-47. Russian. doi: https://doi.org/10.15829/1728-8800-2021-3098

  15. Karamitsos DT. Antiatheromatic effects of insulin. Diabetes Res. Clin. Pract. 2011;93(Suppl. 1):S105-S108. doi: https://doi.org/10.1016/S0168-8227(11)70024-9

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Institute of Therapy and Preventive Medicine — Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    E. V. Stryukova, V. S. Shramko, E. V. Kashtanova, Ya. V. Polonskaya, E. M. Stakhneva & Yu. I. Ragino

  2. E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Novosibirsk, Russia

    A. V. Kurguzov & A. M. Chernyavskiy

Authors
  1. E. V. Stryukova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. S. Shramko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. V. Kashtanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ya. V. Polonskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. M. Stakhneva
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. V. Kurguzov
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. M. Chernyavskiy
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yu. I. Ragino
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. V. Stryukova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 1, pp. 107-111, January, 2023

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Stryukova, E.V., Shramko, V.S., Kashtanova, E.V. et al. Cytokine Profile and Concentrations of Metabolic Hormones in the Blood of Overweight Men with Coronary Arteriosclerosis. Bull Exp Biol Med 175, 92–95 (2023). https://doi.org/10.1007/s10517-023-05817-y

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-023-05817-y

Keywords

Search

Navigation