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Experimental Study of Antidepressant Properties of Afobazole

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We studied the effects of oral administration of Afobazole in a dose of 10 mg/kg for 5 days on depressive-like behavior of male C57BL/6 mice in the tail suspension test in comparison with amitriptyline (10 mg/kg) or fluoxetine (20 mg/kg) treatment. Afobazole produced an antidepressant effect similar to amitriptyline, but inferior to fluoxetine. The σ1 receptor antagonist BD-1047 in a dose of 5 mg/kg blocked the antidepressant effect of Afobazole, which indicates the involvement of σ1 receptors in the antidepressant effect of the drug.

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Authors and Affiliations

  1. V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia

    I. G. Kapitsa, A. A. Alymov, E. V. Savinkova, T. A. Voronina & S. B. Seredenin

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  1. I. G. Kapitsa
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  2. A. A. Alymov
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  3. E. V. Savinkova
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  4. T. A. Voronina
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  5. S. B. Seredenin
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Correspondence to I. G. Kapitsa.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 1, pp. 70-74, January, 2023

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Kapitsa, I.G., Alymov, A.A., Savinkova, E.V. et al. Experimental Study of Antidepressant Properties of Afobazole. Bull Exp Biol Med 175, 59–62 (2023). https://doi.org/10.1007/s10517-023-05811-4

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