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Prevention of the Genotoxic Effects of Doxorubicin with Anthocyanin-Containing Complex from Sorbus aucuparia L. Fruit

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We studied the effect of an anthocyanin-containing complex from the fruits of S. aucuparia L. on doxorubicin-induced genotoxicity in bone marrow cells of C57BL/6 mice. The complex reduced the genotoxic effect doxorubicin in metaphase plates of bone marrow cells in 24, 48 h, and 10 days after the administration of the cytostatic. The mean number of single fragments and the fraction of cells with gaps and aberrant metaphases also decreased.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    O. Yu. Rybalkina, O. V. Neupokoeva, O. L. Voronova, T. G. Razina, E. A. Kiseleva, A. A. Churin, E. P. Zueva & V. V. Zhdanov

  2. Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    G. I. Kalinkina & N. V. Isaikina

Authors
  1. O. Yu. Rybalkina
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  2. O. V. Neupokoeva
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  3. O. L. Voronova
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  4. T. G. Razina
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  5. G. I. Kalinkina
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  6. N. V. Isaikina
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  7. E. A. Kiseleva
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  8. A. A. Churin
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  9. E. P. Zueva
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  10. V. V. Zhdanov
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Corresponding author

Correspondence to O. Yu. Rybalkina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 1, pp. 59-64, January, 2023

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Rybalkina, O.Y., Neupokoeva, O.V., Voronova, O.L. et al. Prevention of the Genotoxic Effects of Doxorubicin with Anthocyanin-Containing Complex from Sorbus aucuparia L. Fruit. Bull Exp Biol Med 175, 49–53 (2023). https://doi.org/10.1007/s10517-023-05809-y

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  • DOI: https://doi.org/10.1007/s10517-023-05809-y

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