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Specifics of Experimental Modeling 8-OH-DPAT-Induced Perseverative Behavior in Mice

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The effect of 5-HT1A receptor agonist 8-OH-DPAT (intraperitoneal injection in doses of 1, 2, and 4 mg/kg) on spontaneous alternation behavior of mice in Y-maze was studied without and with habituation procedure and food reward. In the first case, 8-OH-DPAT administration led to a decrease in spontaneous alternation and locomotor activity in mice. At the same time, 8-OH-DPAT treatment after habituation and food deprivation increased repeated choices of goal arms without affecting locomotor activity, which was consistent with perseverative behavior. 8-OH-DPAT-induced decrease in spontaneous alternation behavior in Y-maze in mice with habituation and food reward is the most suitable procedure for experimental modeling of the perseverative behavior and studying the anticompulsive activity of new substances.

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Authors and Affiliations

  1. V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia

    N. V. Kudryashov, A. V. Volkova, A. A. Shimshirt, P. L. Naplekova, T. A. Voronina & S. B. Seredenin

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  1. N. V. Kudryashov
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  2. A. V. Volkova
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  3. A. A. Shimshirt
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  4. P. L. Naplekova
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  5. T. A. Voronina
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  6. S. B. Seredenin
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Correspondence to N. V. Kudryashov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 1, pp. 50-54, January, 2023

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Kudryashov, N.V., Volkova, A.V., Shimshirt, A.A. et al. Specifics of Experimental Modeling 8-OH-DPAT-Induced Perseverative Behavior in Mice. Bull Exp Biol Med 175, 41–44 (2023). https://doi.org/10.1007/s10517-023-05807-0

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  • DOI: https://doi.org/10.1007/s10517-023-05807-0

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