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Pyridine Derivative of Succinic Acid Hydroxylamide Enhances the Cytotoxic Effect of Cisplatin and Actinomycin D

  • BIOPHYSICS AND BIOCHEMISTRY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the possibility of inhibition of histone deacetylases (HDAC) in the nuclear extract of HeLa cells by N1-hydroxy-N4-(pyridin-4-yl)succinamide (compound 1). Compound 1 inhibits HDAC and showed low toxicity for A-172, HepG2, HeLa, MCF-7, and Vero cells. HeLa cells were most sensitive to the compound. Increasing the interval between administration of compound 1 and the chemotherapeutic agent to 8 h led to an increase in the cytotoxic effect of cisplatin (actinomycin D) on HeLa cells. The combination of compound 1 with cisplatin (actinomycin D) reduced the cytotoxic effect of these drugs for non-tumor Vero cells.

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Authors and Affiliations

  1. Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia

    B. A. Tretyakov, N. V. Filatova, V. A. Mumyatova, S. Y. Gadomsky & A. A. Terent’ev

  2. Scientific and Educational Center of the Moscow State Regional University in Chernogolovka, Medical Biological Institute, Mytishchi, Moscow region, Russia

    A. A. Terent’ev

  3. M. V. Lomonosov Moscow State University, Moscow, Russia

    A. A. Terent’ev

Authors
  1. B. A. Tretyakov
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  2. N. V. Filatova
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  3. V. A. Mumyatova
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  4. S. Y. Gadomsky
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  5. A. A. Terent’ev
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Correspondence to B. A. Tretyakov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 1, pp. 29-33, January, 2023

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Tretyakov, B.A., Filatova, N.V., Mumyatova, V.A. et al. Pyridine Derivative of Succinic Acid Hydroxylamide Enhances the Cytotoxic Effect of Cisplatin and Actinomycin D. Bull Exp Biol Med 175, 23–26 (2023). https://doi.org/10.1007/s10517-023-05803-4

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  • DOI: https://doi.org/10.1007/s10517-023-05803-4

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