We compared the expression of the main glioblastoma oncogenes during therapy with doxorubicin (Dox) and Dox in nanoparticles based on a copolymer of lactic and glycolic acids (Dox-PLGA) at a delayed start of treatment. Late initiation of Dox-PLGA therapy of glioblastoma showed an increase in the expression of multiple drug resistance genes, such as Abcb1b and Mgmt, and a decrease in Sox2 expression. Increased expression of other oncogenes (Melk, Wnt3, Gdnf, and Pdgfra) were observed during both Dox and Dox-PLGA therapy. These changes indicate increased tumor aggressiveness and its resistance to cytostatics at the late start of therapy.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 207-211, December, 2022
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Alekseeva, A.I., Gerasimov, A.D., Kudelkina, V.V. et al. Changes in Oncogene Expression in Experimental Glioblastoma 101.8 Rats during Therapy with PLGA Nanoparticles Loaded with Doxorubicin. Bull Exp Biol Med 174, 518–522 (2023). https://doi.org/10.1007/s10517-023-05740-2
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DOI: https://doi.org/10.1007/s10517-023-05740-2