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Stromal Changes in Colon Blastomogenesis Associated with Development of Hypoxia in the Foci of Dysplasia

  • MORPHOLOGY AND PATHOMORPHOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the features of reaction of the colon stromal cells (lymphohistiocytic population, fibroblasts, and blood vessels) to the appearance and progression of dysplasia in the colon epithelium against the background of increasing ischemia in the colon mucosa. The morphological material from 92 patients treated for benign processes and colon cancer in 2002-2016 was examined. Common histological methods and a complex immunohistochemical staining were used. The stromal cells of the colon mucosa, mainly lymphohistiocytic cells, undergo certain quantitative changes specific for each type of cells during progression of dysplasia and aggravation of ischemia in the mucosa. Some cells, e.g. plasma cells, presumably contribute to tissue hypoxia in the stroma. Most stromal cells, except interdigitating S100+ dendritic cells and CD10+ fibroblasts, decreased at the stage of grave dysplasia and cancer in situ. Low effectiveness of the immune defense can be partly explained by impairment of the function of stromal cells as a result of hypoxia in the microenvironment.

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Authors and Affiliations

  1. Department of Morphological and Molecular Genetic Tumor Diagnostics, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia

    A. I. Karseladze

  2. Department of Oncopathology, V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia

    A. I. Karseladze

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  1. A. I. Karseladze
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Correspondence to A. I. Karseladze.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 10, pp. 515-522, October, 2022

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Karseladze, A.I. Stromal Changes in Colon Blastomogenesis Associated with Development of Hypoxia in the Foci of Dysplasia. Bull Exp Biol Med 174, 502–508 (2023). https://doi.org/10.1007/s10517-023-05737-x

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  • DOI: https://doi.org/10.1007/s10517-023-05737-x

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