We evaluated antitumor efficacy of photodynamic therapy of murine Ehrlich carcinoma and rat sarcoma M-1 with new photosensitizers 131-N-(4-aminobutyl)amydo chlorine e6 (1), 132-(5-guanidylbutanamido)-chlorine e6 (2), and 132-(5-biguanidylbutanamido)-chlorine e6 (3). The inhibiting effect of the photodynamic therapy was evaluated by the following parameters: tumor growth inhibition, complete regression of the tumors, and absolute growth rate of the tumor nodes in animals with the continued neoplasia growth. The criterion of cure was the absence of tumors up to 90 days after the therapy. It is shown that the studied photosensitizers have high antitumor activity in the photodynamic therapy of the Ehrlich carcinoma and sarcoma M-1.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Stranadko EPh. Photodynamic therapy: state-of-art. Laser. Med. 2021;25(S3):36. Russian. doi: https://doi.org/10.37895/2071-8004-2021-25-3S-36
Machinskaya EA, Ivanova-Radkevich VI. Review of selective accumulation of photosensitizers with different chemical structure in tumor tissue. Fotodinam. Ter. Fotodiag. 2013;2(4):19-23. Russian.
Lukiyanets EA. Search for new photosensitizers in photodynamic therapy. Fotodinam. Ter. Fotodiag. 2013;2(3):3-16. Russian.
Kruglov SS, Gelfond ML, Tyndyk ML, Maydin MA, Grishacheva TG, Basina RM, Gubareva EA, Plakhov EA, Kireeva GS, Panchenko AV. Methodological aspects of photodynamic therapy of ehrlich solid carcinoma in BALB/c mouse strain with various tumor localization. Sib. Onkol. Zh. 2020;19(6):82-92. Russian. doi: https://doi.org/10.21294/1814-4861-2020-19-6-82-92
Brusov SS, Efremenko AV, Lebedeva VS, Shchepelina EYu, Ponomarev PhV, Feofanov AV, Mironov AF, Grin MA. Influence of a positive charge in the structure of photosensitizers of chlorin series on the photoinduced anticancer activity. Ros. Bioter. Zh. 2015;14(4):87-92. Russian. doi: https://doi.org/10.17650/1726-9784-2015-14-4-87-92
Akhmedova DA, Shatalov DO, Ivanov IS, Aydakova AV, Herbst A, Greiner L, Kaplun AP, Zhurbenko AS, Kedik SA. The use of microfluidic hardware in the synthesis of oligohexamethylene guanidine derivatives. Tonkie Khim. Tekhnol. 2021;16(4):307-317. Russian. doi: https://doi.org/10.32362/2410-6593-2021-16-4-307-317
Abramova OB, Drozhzhina VV, Churikova TP, Kozlovtceva EA, Arkhipova LM, Kaplan MA, Ivanov SA, Kaprin AD. Photodynamic therapy of the experimental tumors of different morphological types with liposomal boronated chlorin e6. Biomedical Photonics. 2021;10(3):12-22. Russian. doi: https://doi.org/10.24931/2413-9432-2021-10-3-12-22
Abramova OB, Kaplan MA, Yuzhakov VV, Drozhzhina VV, Churikova TP, Kozlovtseva EA, Bandurko LN, Yakovleva ND, Sevankaeva LE, Tsyganova MG, Ivanov SA, Kaprin AD. Efficiency of photosensitizer chlorin e6 dimethyl ether for photodynamic therapy of rat sarcoma M-1. Radiatsiya Risk. 2022;31(2):151-161. Russian. doi: https://doi.org/10.21870/0131-3878-2022-31-2-151-161
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 10, pp. 477-482, October, 2022
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Abramova, O.B., Kozlovtseva, E.A., Drozhzhina, V.V. et al. Anti-Tumor Efficacy of Photodynamic Therapy of Solid Tumors in Laboratory Animals with Guanidine and Biguanidine Derivatives of Chlorine e6. Bull Exp Biol Med 174, 468–472 (2023). https://doi.org/10.1007/s10517-023-05731-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-023-05731-3