A comparative analysis of specific immunobiochemical parameters, including natural antibodies (NAb) to endogenous regulators of the cardiovascular system, adrenal and gastrointestinal hormones, was performed in students aged 18-22 years with normal and increased body weight (the body mass index from 18.5 to 24.9 kg/m2 and from 25 to 29.9 kg/m2, respectively). The serum content of NAb and hormones was determined by ELISA. The level of the studied indicators depended on the body mass index value. In overweight subjects, the main immune indicators of the biogenic amine system, renin-angiotensin system, and kinin system exceeded the normal. The cortisol level was higher than in subjects with normal body weight. Aldosterone secretion was less dependent on the ACTH content and was lower than in students with normal body weight. The content of cholecystokinin and gastrin corresponded to the values for overweight. These trends in hormone contents are a predisposing factor for further weight gain. Practical significance of the combined assessment of disturbances in the immunological and biochemical homeostasis has been established. Analysis of the adrenal and gastrointestinal hormones can predict the risk of weight gain, but at the same time, changes in the level of immunological indicators in subjects with increased body weight characterizes the possibility of developing cardiovascular pathologies.
Similar content being viewed by others
References
Nikityuk DB. Anthropo-nutritionology in solving the problems of health protection and prevention of alimentary-dependent diseases. Voprosy Pitan. 2018;87(Suppl. 5):68. Russian. https://doi.org/10.24411/0042-8833-2018-10154
Filaretova LP. Stress in physiological studies. Neurosci. Behav. Physiol. 2012;42(2):193-199. https://doi.org/10.1007/s11055-011-9552-0
Martinchik AN, Baturin AK, Kambarov AO. Analysis of the association of diet energy from macronutrients and prevalence of overweight and obesity among the Russian population. Voprosy Pitan. 2020;89(3):40-53. Russian. https://doi.org/10.24411/0042-8833-2020-10028
Lai CQ, Parnell LD, Smith CE, Guo T, Sayols-Baixeras S, Aslibekyan S, Tiwari HK, Irvin MR, Bender C, Fei D, Hidalgo B, Hopkins PN, Absher DM, Province MA, Elosua R, Arnett DK, Ordovas JM. Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A. Am. J. Clin. Nutr. 2020;112(5):1200-1211. https://doi.org/10.1093/ajcn/nqaa233
Vybornaya KV, Sokolov AI, Kobelkova IV, Lavrinenko SV, Klochkova SV, Nikityuk DB. Basal metabolic rate as an integral indicator of metabolism intensity. Voprosy Pitan. 2017;86(5):5-10. Russian.
Dedov II, Shestakova MV, Galstyan GR. The prevalence of type 2 diabetes mellitus in the adult population of Russia (nation study). Sakhar. Diabet. 2016;19(2):104-112. Russian. https://doi.org/10.14341/DM2004116-17
Saygitov RT, Chulok AA. Cardiovascular diseases in the context of Russia’s long-term socio-economic development priorities. Vestn. RAMN. 2015;70(3):286-299. Russian. https://doi.org/10.15690/vramn.v70i3.1324
Frank AP, de Souza Santos R, Palmer BF, Clegg DJ. Determinants of body fat distribution in humans may provide insight about obesity-related health risks J. Lipid Res. 2019;60(10):1710-1719. https://doi.org/10.1194/jlr.R086975
Myagkova MA, Morozova VS. Natural antibodies and their physiological function. Immunopatol. Allergol. Infectol. 2014;(3):75-81. Russian. https://doi.org/10.14427/jipai.2014.3.75
Kryzhanovskii GN, Akmaev GN, Magaeva SV, Morozov SG. Neuroimmunoendocrine Interactions in Norm and Pathology. Moscow, 2010. Russian.
Igon’kina SI, Vetrile LA, Kukushkin ML. Effect of Anti-Norepinephrine Antibodies on the Development of Neuropathic Pain. Bull. Exp. Biol. Med. 2017;162(6):714-717. https://doi.org/10.1007/s10517-017-3695-0
Madi A, Hecht I, Bransburg-Zabary S, Merbl Y, Pick A, Zucker-Toledano M, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E. Organization of the autoantibody repertoire in healthy newborns and adults revealed by system level informatics of antigen microarray data. Proc. Natl Acad. Sci. USA. 2009;106(34):14 484-14 489. https://doi.org/10.1073/pnas.0901528106
Myagkova MA, Petrochenko SN, Morozova VS. Detection of natural antibodies to endogenous bioregulators for the diagnostics of the functional state of the body. Rus. Chem. Bull. 2018;67(4):762-767. https://doi.org/10.1007/s11172-018-2134-3
Chesnokova NP, Ponukalina EV, Zhevak TN, Bizenkova MN. The Role of Adenohypophysis Hormones in the Regulation of Metabolic, in Particular Water-Salt, Homeostasis in Conditions of Norm and Pathology. Nauch. Obozrenie Med. Nauki. 2016;(1):58-60. Russian.
Zagoskin PP, Zagoskina IP, Savelieva NA, Lyalyaev VA. Modern Approaches to the Problem of Body Weight Regulation (Review). Sovrem. Tekhnol. Med. 2014;6(3):104-117. Russian.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 10, pp. 452-456, October, 2022
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Myagkova, M.A., Orlova, E.A., Petrochenko, S.N. et al. Analysis of Immunobiochemical Parameters in Overweight People in Assessing the Risk of Cardiovascular Diseases. Bull Exp Biol Med 174, 446–450 (2023). https://doi.org/10.1007/s10517-023-05726-0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-023-05726-0