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Features of the Free Radical Oxidation Process and Antioxidant System in Newborns Born to HIV-Infected of Mothers Who Received Antiretroviral Therapies to Prevent HIV Transmission

  • GENERAL PATHOLOGY AND PATHOLOGICAL PHYSIOLOGY
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The LPO processes and the state of the antioxidant system in perinatally HIV-exposed newborns were studied. Perinatally HIV-exposed (n=62) and healthy newborns (n=80; control) were examined retrospectively (Apgar score 8 in both groups). Blood plasma and erythrocyte hemolysate were used as the material for biochemical tests. Using spectrophotometric, fluorometric, and statistical methods, we found enhanced LPO processes insufficiently compensated by the antioxidant system with excessive accumulation of damaging metabolites in the blood of perinatally HIV-exposed newborns. These changes can be a consequence of oxidative stress during the perinatal period.

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Authors and Affiliations

  1. Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia

    N. A. Kurashova, A. S. Vanyarkina, A. G. Petrova, L. V. Rychkova, S. I. Kolesnikov, M. A. Darenskaya, E. V. Moskaleva & L. I. Kolesnikova

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  1. N. A. Kurashova
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  2. A. S. Vanyarkina
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  3. A. G. Petrova
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  4. L. V. Rychkova
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  5. S. I. Kolesnikov
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  6. M. A. Darenskaya
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  7. E. V. Moskaleva
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  8. L. I. Kolesnikova
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Corresponding author

Correspondence to N. A. Kurashova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 10, pp. 414-418, October, 2022

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Kurashova, N.A., Vanyarkina, A.S., Petrova, A.G. et al. Features of the Free Radical Oxidation Process and Antioxidant System in Newborns Born to HIV-Infected of Mothers Who Received Antiretroviral Therapies to Prevent HIV Transmission. Bull Exp Biol Med 174, 413–416 (2023). https://doi.org/10.1007/s10517-023-05719-z

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  • DOI: https://doi.org/10.1007/s10517-023-05719-z

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