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Hypolypidemic Activity of L-Rhamnopyranosyl-6-O-Methyl-D-Galacturonan, a Polysaccharide Isolated from Birch Leaves (Betula pendula L.)

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In male Syrian hamsters fed a synthetic high-fat diet enriched with cholesterol (0.3%), administration of a polysaccharide from birch leaves L-rhamnopyranosyl-6-O-methyl-D-galacturonan (3 g/100 g of diet) resulted in a decrease in total cholesterol levels, mainly due to the LDL fraction, triglycerides, and bile acids in blood serum; the content of triglycerides and cholesterol in the liver also decreased, while excretion of bile acids with feces increased. Thus, the lipid-lowering effect of L-rhamnopyranosyl-6-O-methyl-D-galacturonan is related to its ability to bind bile acids in the intestine and interrupt their enterohepatic circulation.

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Authors and Affiliations

  1. Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    E. E. Buyko, V. V. Ivanov, O. A. Kaidash, S. V. Krivoshchekov, A. M. Gur’ev & M. V. Belousov

  2. National Research Tomsk Polytechnic University, Tomsk, Russia

    E. E. Buyko & M. V. Belousov

  3. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    O. Yu. Rybalkina & E. A. Kiseleva

Authors
  1. E. E. Buyko
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  2. V. V. Ivanov
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  3. O. A. Kaidash
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  4. O. Yu. Rybalkina
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  5. E. A. Kiseleva
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  6. S. V. Krivoshchekov
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  7. A. M. Gur’ev
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  8. M. V. Belousov
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Correspondence to E. E. Buyko.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 9, pp. 315-318, September, 2022

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Buyko, E.E., Ivanov, V.V., Kaidash, O.A. et al. Hypolypidemic Activity of L-Rhamnopyranosyl-6-O-Methyl-D-Galacturonan, a Polysaccharide Isolated from Birch Leaves (Betula pendula L.). Bull Exp Biol Med 174, 330–332 (2023). https://doi.org/10.1007/s10517-023-05702-8

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  • DOI: https://doi.org/10.1007/s10517-023-05702-8

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