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Steroid Hormones in Seminal Plasma: the Relationship with Sperm Quality

  • BIOPHYSICS AND BIOCHEMISTRY
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Bulletin of Experimental Biology and Medicine Aims and scope

The purpose of this study was to find out whether the seminal testosterone and/or estradiol levels could serve as prognostic criteria for normal spermatogenesis and whether they are able to characterize the sperm pathology. The study involved healthy young male volunteers (n=269); serum and seminal steroid hormones were measured; the sperm concentration, mobility, and morphology were evaluated. The results indicate that the seminal testosterone concentration is lower (p<0.05) and the seminal estradiol is higher than the corresponding parameters in the serum (p<0.05). The seminal testosterone and estradiol concentrations negatively correlated with the sperm concentration, and the seminal estradiol concentration was higher in pathozoospermic than in normospermic men (p<0.05). It is assumed that the seminal estradiol level can be an indicator of sperm quality and serve as a biological predictor of normal spermatogenesis; in addition, this parameter can be used for diagnostic purposes in patients with impaired spermatogenesis induced by excess of estrogens.

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References

  1. Rodriguez-Martinez H, Martinez EA, Calvete JJ, Peña Vega FJ, Roca J. Seminal Plasma: Relevant for Fertility? Int. J. Mol. Sci. 2021;22(9):4368. https://doi.org/10.3390/ijms22094368

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Vitku J, Kolatorova L, Hampl R. Occurrence and reproductive roles of hormones in seminal plasma. Basic Clin. Androl. 2017;27:19. https://doi.org/10.1186/s12610-017-0062-y

    Article  PubMed  PubMed Central  Google Scholar 

  3. Hampl R, Kubátová J, Sobotka V, Heráček J. Steroids in semen, their role in spermatogenesis, and the possible impact of endocrine disruptors. Horm. Mol. Biol. Clin. Investig. 2013;13(1):1-5. https://doi.org/10.1515/hmbci-2013-0003

    Article  CAS  PubMed  Google Scholar 

  4. Ramaswamy S, Weinbauer GF. Endocrine control of spermatogenesis: Role of FSH and LH/ testosterone. Spermatogenesis. 2015;4(2):e996025. https://doi.org/10.1080/21565562.2014.996025

  5. Jørgensen N, Joensen UN, Toppari J, Punab M, Erenpreiss J, Zilaitiene B, Paasch U, Salzbrunn A, Fernandez MF, Virtanen HE, Matulevicius V, Olea N, Jensen TK, Petersen JH, Skakkebæk NE, Andersson AM. Compensated reduction in Leydig cell function is associated with lower semen quality variables: a study of 8182 European young men. Hum. Reprod. 2016;31(5):947-957. https://doi.org/10.1093/humrep/dew021

    Article  CAS  PubMed  Google Scholar 

  6. Osadchuk L, Tipisova E, Kleshchev M, Gorenko I, Osadchuk A. Study of Semen Quality, Reproductive Hormone Levels, and Lipid Levels in Men From Arkhangelsk, a City in North of European Russia. Am. J. Mens Health. 2020;14(4):1557988320939714. https://doi.org/10.1177/1557988320939714

    Article  PubMed  PubMed Central  Google Scholar 

  7. Zhang Q, Bai Q, Yuan Y, Liu P, Qiao J. Assessment of seminal estradiol and testosterone levels as predictors of human spermatogenesis. J. Androl. 2010;31(2):215-220. https://doi.org/10.2164/jandrol.109.007609

    Article  CAS  PubMed  Google Scholar 

  8. Vitku J, Sosvorova L, Chlupacova T, Hampl R, Hill M, Sobotka V, Heracek J, Bicikova M, Starka L. Differences in bisphenol A and estrogen levels in the plasma and seminal plasma of men with different degrees of infertility. Physiol. Res. 2015;64(Suppl. 2.):S303-S311. https://doi.org/10.33549/physiolres.933090

  9. Collodel G, Signorini C, Nerucci F, Gambera L, Iacoponi F, Moretti E. Semen Biochemical Components in Varicocele, Leukocytospermia, and Idiopathic Infertility. Reprod. Sci. 2021;28(1):91-101. https://doi.org/10.1007/s43032-020-00260-0

    Article  CAS  PubMed  Google Scholar 

  10. Zufferey F, Rahban R, Garcia A, Gagnebin Y, Boccard J, Tonoli D, Jeanneret F, Stettler E, Senn A, Nef S, Rudaz S, Rossier MF. Steroid profiles in both blood serum and seminal plasma are not correlated and do not reflect sperm quality: Study on the male reproductive health of fifty young Swiss men. Clin. Biochem. 2018;62:39-46. https://doi.org/10.1016/j.clinbiochem.2018.03.008

    Article  CAS  PubMed  Google Scholar 

  11. Onaran I, Aydemir B, Kiziler AR, Demiryurek T, Alici B. Relationships between levels of estradiol and testosterone in seminal plasma and GSTM1 polymorphism in infertile men. Arch. Androl. 2007;53(1):13-16. https://doi.org/10.1080/01485010600889134

    Article  CAS  PubMed  Google Scholar 

  12. WHO Laboratory Manual for the Examination and Processing of Human Semen, 5th ed. WHO, 2010.

  13. Cooke PS, Nanjappa MK, Ko C, Prins GS, Hess RA. Estrogens in Male Physiology. Physiol. Rev. 2017;97(3):995-1043. https://doi.org/10.1152/physrev.00018.2016

    Article  PubMed  PubMed Central  Google Scholar 

  14. Thanaboonyawat I, Chantrapanichkul P, Petyim S, Kaewjunun C, Laokirkkiat P, Choavaratana R. Application of testosterone supplementation in semen to improve sperm motility in asthenozoospermic males. Arch. Gynecol. Obstet. 2017;296(3):589-596. https://doi.org/10.1007/s00404-017-4451-4

    Article  CAS  PubMed  Google Scholar 

  15. Yang C, Li P, Li Z. Clinical application of aromatase inhibitors to treat male infertility. Hum. Reprod. Update. 2021;28(1):30-50. https://doi.org/10.1093/humupd/dmab036

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    L. V. Osadchuk, M. A. Kleshchev & A. V. Osadchuk

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  1. L. V. Osadchuk
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  2. M. A. Kleshchev
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  3. A. V. Osadchuk
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Correspondence to L. V. Osadchuk.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 9, pp. 301-305, September, 2022

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Osadchuk, L.V., Kleshchev, M.A. & Osadchuk, A.V. Steroid Hormones in Seminal Plasma: the Relationship with Sperm Quality. Bull Exp Biol Med 174, 318–321 (2023). https://doi.org/10.1007/s10517-023-05699-0

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  • DOI: https://doi.org/10.1007/s10517-023-05699-0

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