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Structural and Functional Changes of the Thoracic Aorta in Experimental Arterial Hypertension

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Bulletin of Experimental Biology and Medicine Aims and scope

The functional characteristics of the thoracic aorta in Wistar rat with experimental arterial hypertension were studied using MRI. The intravital images of the aorta were obtained using a synchronizer of cardiac and respiratory cycles. The pulse-gradient Turbo-spin-echo sequence and the BODY CARDIAC movie 10 mode were used. The unfavorable factor of increased BP initiated structural and functional changes in the thoracic aorta. At the initial stages, they manifested by an increase of the lumen and a decrease in endothelium-dependent vasodilation. Progression of arterial hypertension (3-6 months) was associated with narrowing of the lumen of both ascending and descending parts of the aorta. Deformation of the aortic arch due to increased density of the vascular wall was observed by the sixth month of the development of arterial hypertension.

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References

  1. Larina OM, Mershina EA, Sinitsyn VE, Andreev DA. Cardiac magnetic resonance imaging in the diagnosis of acute myocarditis: a clinical case and a review of literature. Vestn. Rentgenol. Radiol. 2014;(5):54-59. Russian.

  2. Mareev VYu, Fomin IV, Ageev FT, Arutyunov GP, Begrambekova YuL, Belenkov YuN, Vasyuk YuA, Galyavich AS, Garganeeva AA, Gendlin GE, Gilyarevsky SR, Glezer MG, Drapkina OM, Duplyakov DV, Kobalava ZhD, Koziolova NA, Lopatin YuM, Mareev YuV, Moiseev VS, Nedoshivin AO, Perepech NB, Sitnikova MYu, Skibitsky VV, Tarlovskaya EI, Chesnikova AI, Shlyakhto EV. Clinical guidelines. Chronic heart failure (CHF). Zh. Serdech. Nedostat. 2017;18(1):3-40. Russian. https://doi.org/10.18087/rhfj.2017.1.2346

  3. Medvedev IN, Skoryatina IA. Aggregation properties of blood cells and vascular control over them in patients with arterial hypertension and dyslipidemia. Ross. Zh. Kardiol. 2015;(4):18-22. Russian. https://doi.org/10.15829/1560-4071-2015-04-18-22

  4. Agafonova IG, Bogdanovich RN, Kolosova NG. Assessment of nephroprotective potential of histochrome during induced arterial hypertension. Bull. Exp. Biol. Med. 2015;160(2):187-191. https://doi.org/10.1007/s10517-015-3134-z

    Article  CAS  Google Scholar 

  5. Podzolkov VI, Bragina AE, Bragina GI, Murashko NA. The state of nitroxide production function of endothelium and left ventricle hypertrophy in arterial hypertension. Kardiovaskular. Ter. Prof. 2017;16(4):11-17. Russian. https://doi.org/10.15829/1728-8800-2017-4-11-17

  6. Agafonova IG, Kotel’nikov VN, Mischenko NP, Kolosova NG. Evaluation of effects of histochrome and mexidol on structural and functional characteristics of the brain in senescence-accelerated OXYS rats by magnetic resonance imaging. Bull. Exp. Biol. Med. 2011;150(6):739-743. https://doi.org/10.1007/s10517-011-1238-7

  7. Agafonova IG, Kotel’nikov VN, Geltser BI. Magnetic resonance imaging in assessment of cardiac remodeling in rats with experimental arterial hypertension. Bull. Exp. Biol. Med. 2019;167(3):320-324. https://doi.org/10.1007/s10517-019-04518-9

  8. Antonov YeV, Alexandrovich YuV, Seryapina AA, Klimov LO, Markel AL. Stress and arterial hypertension: ISIAH rat strain. Vavilov. Zh. Gen. Selek. 2015;19(4):455-459. Russian. https://doi.org/10.18699/VJ15.060

  9. Novgorodtseva TP, Antonyuk MV, Karaman YuK, Kotelnikov VN, Gvozdenko TA, Korolev IB, Agafonova IG. Modeling of cardiovasorenal arterial hypertension in rats. Patol. Fiziol. Eksper. Ter. 2008;(4):34-36. Russian.

  10. Geltser BI, Kotelnikov VN, Agafonova IG, Korolev IB, Antonyuk MV, Karaman JK, Li V, Lukyanov PA. Endothelial disfunction of cerebral blood vessels at arterial hypertension. Byull. Fiziol. Patol. Dykhaniya. 2007;(25):22-24. Russian.

  11. Teregulov YE, Teregulov AE. The rigidity of the arterial system as a risk factor for cardiovascular events: methods of assessment. Prakt. Med. 2011;(4):133-137. Russian.

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Authors and Affiliations

  1. G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Division of the Russian Academy of Sciences, Vladivostok, Russia

    I. G. Agafonova

  2. State Research Test Institute of Military Medicine, Ministry of Defense of the Russian Federation, St. Petersburg, Russia

    V. N. Kotelnikov

  3. Far Eastern Federal University, Vladivostok, Russia

    B. I. Geltser

Authors
  1. I. G. Agafonova
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  2. V. N. Kotelnikov
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  3. B. I. Geltser
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Correspondence to I. G. Agafonova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 9, pp. 289-293, September, 2022

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Agafonova, I.G., Kotelnikov, V.N. & Geltser, B.I. Structural and Functional Changes of the Thoracic Aorta in Experimental Arterial Hypertension. Bull Exp Biol Med 174, 308–311 (2023). https://doi.org/10.1007/s10517-023-05697-2

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  • DOI: https://doi.org/10.1007/s10517-023-05697-2

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