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Mechanisms of Modulation of Adrenergic Regulation of Spontaneous Activity Rate and Atrial Myocardial Contractility in Early Postnatal Ontogeny in Rats

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We studied combined effect of the β1,2-adrenoreceptor agonist isoproterenol and the Y1,5 receptor agonist [Leu31, Pro34]neuropeptide Y on the frequency of spontaneous activity and myocardial contractility in 21- and 100-day-old rats. Isoproterenol increased the frequency of spontaneous activity and reduced the main parameters of isometric contraction of the atrial myocardium. When [Leu31, Pro34]neuropeptide Y was added, the frequency of spontaneous activity and the negative inotropic and the positive chronotropic effects of isoproterenol were reduced in 100-day-old rats. In 21-day-olds rats, a tendency to a decrease in the effect of isoproterenol was observed.

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Authors and Affiliations

  1. Department of Human Health Protection, Kazan (Volga region) State University, Kazan, Republic of Tatarstan, Russia

    N. G. Iskakov, T. A. Anikina, F. G. Sitdikov & T. L. Zefirov

Authors
  1. N. G. Iskakov
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  2. T. A. Anikina
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  3. F. G. Sitdikov
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  4. T. L. Zefirov
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Correspondence to N. G. Iskakov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 9, pp. 274-277, September, 2022

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Iskakov, N.G., Anikina, T.A., Sitdikov, F.G. et al. Mechanisms of Modulation of Adrenergic Regulation of Spontaneous Activity Rate and Atrial Myocardial Contractility in Early Postnatal Ontogeny in Rats. Bull Exp Biol Med 174, 295–298 (2023). https://doi.org/10.1007/s10517-023-05694-5

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  • DOI: https://doi.org/10.1007/s10517-023-05694-5

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