We studied the effect of prenatal stress (dams were forced to swim in cold water (10°C; 5 min) from day 10 to 16 of gestation) on the behavioral parameters of the offspring in an elevated plus maze on days 21, 30, and 60 of life (suckling, infantile, and juvenile ages, respectively). Females at the suckling age demonstrated suppressed orientation and exploratory activity and increased anxiety, which returned to normal by the infantile and juvenile periods. Prenatally stressed males in juvenile age were characterized by reduced anxiety (assessed by the time spent in the closed and open arms of the plus maze). Thus, the effect of prenatal stress on the behavioral parameters manifested differently depending on the sex and stage of postnatal ontogeny. The modulatory effects of prenatal stress on the analyzed behavioral parameters were more pronounced in females at early stages of postnatal ontogeny (suckling and infantile ages).
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Scheinost D, Sinha R, Cross SN, Kwon SH, Sze G, Constable RT, Ment LR. Does prenatal stress alter the developing connectome? Pediatr. Res. 2017;81(1-2):214-226. https://doi.org/10.1038/pr.2016.197
Van Batenburg-Eddes T, Brion MJ, Henrichs J, Jaddoe VW, Hofman A, Verhulst FC, Lawlor DA, Davey Smith G, Tiemeier H. Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study. J. Child Psychol. Psychiatry. 2013;54(5):591-600. https://doi.org/10.1111/jcpp.12023
Volodina MA, Sebentsova EA, Levitskaya NG, Kamenskii AA. Studies of the delayed effects of acute prenatal stress evoked by forced swimming. Neurosci. Behav. Physiol. 2012;42(4):362-369. https://doi.org/10.1007/s11055-012-9575-1
Jia N, Li Q, Sun H, Song Q, Tang G, Sun Q, Wang W, Chen R, Li H, Zhu Z. Alterations of Group I mGluRs and BDNF Associated with Behavioral Abnormity in Prenatally Stressed Offspring Rats. Neurochem. Res. 2015;40(5):1074-1082. https://doi.org/10.1007/s11064-015-1565-6
Belyaeva LE, Fedchenko AN, Ligetskaya IV, Kovzova EI, Stolyarova VN. The influence of combined prenatal stress on physical endurance, pain sensitivity and rats’ behaviour. Vestn. Vitebsk. Gos. Med. Univ. 2015;14(1):26-33. Russian.
Nikitina YuV, Mukhina IV. Age-related changes of oxidizing processes in cerebral tissue and blood of rats. Vestn. Nizhny Novgorod Gos. Univ. N. I. Lobachevsky. 2009;6(1):124-131. Russian.
Lynn DA, Brown GR. The ontogeny of anxiety-like behavior in rats from adolescence to adulthood. Dev. Psychobiol. 2010;52(8):731-739. https://doi.org/10.1002/dev.20468
Ordyan NE, Smolenskii IV, Pivina SG, Akulova VK. Characteristics of the formation of the anxious-depressive state in an experimental model of post-traumatic stress disorder in prenatally stressed male rats. Neurosci. Behav. Physiol. 2014;44(6):657-663. https://doi.org/10.1007/s11055-014-9966-6
Braithwaite EC, Pickles A, Sharp H, Glover V, O’Donnell KJ, Tibu F, Hill J. Maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent manner. Physiol. Behav. 2017;175:31-36. https://doi.org/10.1016/j.physbeh.2017.03.017
Sashkov VA, Sel’verova NB, Ermakova IV. Age and sex characteristics of behavior and the level of steroid hormones in the brain of rats in the neonatal and early postnatal period of development. Novye Issled. 2008;(1):52-60. Russian.
Parducz A, Hajszan T, Maclusky NJ, Hoyk Z, Csakvari E, Kurunczi A, Prange-Kiel J, Leranth C. Synaptic remodeling induced by gonadal hormones: neuronal plasticity as a mediator of neuroendocrine and behavioral responses to steroids. Neuroscience. 2006;138(3):977-985. https://doi.org/10.1016/j.neuroscience.2005.07.008
Graf AV, Dunaeva TY, Maklakova AS, Maslova MV, Sokolova NA. Transgenerational effects of prenatal stress of different etiology. Biol. Bull. 2012;39(5):448-457. https://doi.org/10.1134/S1062359012050068
Sudakov SK, Nazarova GA, Alekseeva EV, Bashkatova VG. Estimation of the level of anxiety in rats: differences in results of open-field test, elevated plus-maze test, and Vogel’s conflict test. Bull. Exp. Biol. Med. 2013;155(3):295-297. https://doi.org/10.1007/s10517-013-2136-y
Pertsov SS, Alekseeva IV, Koplik EV, Sharanova NE, Kirbaeva NV, Gapparov MMG. Dynamics of locomotor activity and heat production in rats after acute stress. Bull. Exp. Biol. Med. 2014;157(1):10-14. https://doi.org/10.1007/s10517-014-2479-z
Cannizzaro C, Plescia F, Martire M, Gagliano M, Cannizzaro G, Mantia G, Cannizzaro E. Single, intense prenatal stress decreases emotionality and enhances learning performance in the adolescent rat offspring: interaction with a brief, daily maternal separation. Behav. Brain Res. 2006;169(1):128-136. https://doi.org/10.1016/j.bbr.2005.12.010
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 9, pp. 268-273, September, 2022
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Martyusheva, A.S., Subbotina, A.Y., Abramova, A.Y. et al. Behavior of In Utero Stressed Rats in the Elevated Plus Maze Test during Different Periods of Postnatal Ontogeny. Bull Exp Biol Med 174, 291–294 (2023). https://doi.org/10.1007/s10517-023-05693-6
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DOI: https://doi.org/10.1007/s10517-023-05693-6