The antiviral activity of technologically processed antibodies to CD4 receptor was evaluated a model of sublethal A/California/04/2009 (H1N1)pdm09-induced influenza infection in female BALB/c mice. The technologically processed antibodies increased animal survival rate by 50% in comparison with the placebo group (p<0.05), which correlated with significant inhibition of virus replication in the lungs (p<0.05). The reference drug Tamiflu increased mouse survival rate (by 47%), decreased the virus titer in the lungs, and prevented body weight loss (p<0.05 in comparison with the placebo group by all parameters). The intrinsic protective activity of technologically processed antibodies to CD4 receptor was demonstrated, which manifested in a decrease in viral load in the lower respiratory tract and an increase in the survival rate.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 8, pp. 217-221, August, 2022
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Petrova, N.V., Emelyanova, A.G., Tarasov, S.A. et al. Antiviral Activity of Technologically Processed Antibodies to CD4 Receptor against Influenza Infection. Bull Exp Biol Med 174, 250–253 (2022). https://doi.org/10.1007/s10517-023-05683-8
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DOI: https://doi.org/10.1007/s10517-023-05683-8