Skip to main content
SpringerLink
Log in

Age-Related Features of Ketanserin Effects in Experimental Liver Cirrhosis

  • PHARMACOLOGY AND TOXICOLOGY
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The effect of ketanserin on inflammation, liver fibrosis, and microviscosity of the plasma and mitochondrial membranes of hepatocytes was studied on young (3 months) and old (9 months) male Wistar rats with experimental liver cirrhosis. Ketanserin reduced inflammation, area of the connective tissue, and liver damage and improved serum biochemical parameters in rats of both age groups; in old rats, the effects were more pronounced than in young animals. In old rats, ketanserin reduced polarity of hepatocyte plasma and mitochondrial membranes in the area of protein-lipid contacts, which determined higher effectiveness of ketanserin during the treatment of liver cirrhosis in aged animals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. World Health Organization. Global Status Report on Alcohol and Health 2018. World Health Organization. URL: https://apps.who.int/iris/handle/10665/274603

  2. Osna NA, Donohue TM Jr, Kharbanda KK. Alcoholic Liver Disease: Pathogenesis and Current Management. Alcohol Res. 2017;38(2):147-161.

    Google Scholar 

  3. Kodidela S, Shaik FB, Mittameedi CM, Chintha V, Nallanchakravarthula V. Alcohol exacerbated biochemical and biophysical alterations in liver mitochondrial membrane of diabetic male Wistar rats – A possible amelioration by green tea. Clin. Nutr. Open Sci. 2022;42:130-147. doi: https://doi.org/10.1016/j.nutos.2022.02.004

    Article  Google Scholar 

  4. Zhu SY, Dong Y, Tu J, Zhou Y, Zhou XH, Xu B. Silybum marianum oil attenuates oxidative stress and ameliorates mitochondrial dysfunction in mice treated with D-galactose. Pharmacogn. Mag. 2014;10(Suppl. 1):S92-S99. doi: https://doi.org/10.4103/0973-1296.127353

    Article  Google Scholar 

  5. Ruddell RG, Oakley F, Hussain Z, Yeung I, Bryan-Lluka LJ, Ramm GA, Mann DA. A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. Am. J. Pathol. 2006;169(3):861-876. doi: https://doi.org/10.2353/ajpath.2006.050767

    Article  CAS  Google Scholar 

  6. Marzioni M, Glaser S, Francis H, Marucci L, Benedetti A, Alvaro D, Taffetani S, Ueno Y, Roskams T, Phinizy JL, Venter J, Fava G, Lesage GD, Alpini G. Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin. Gastroenterology. 2005;128(1):121-137. doi: https://doi.org/10.1053/j.gastro.2004.10.002

    Article  CAS  Google Scholar 

  7. Mann DA, Oakley F. Serotonin paracrine signaling in tissue fibrosis. Biochim. Biophys. Acta. 2013;1832(7):905-910. doi: https://doi.org/10.1016/j.bbadis.2012.09.009

    Article  CAS  Google Scholar 

  8. Skurikhin EG, Afanas’ev SA, Zhukova MA, Rebrova TYu, Muslimova EF, Pan ES, Ermakova NN, Pershina OV, Pakhomova AV, Putrova OD, Sandrikina LA, Kogai LV, Dygai AM. Age-related features of the viscosity of plasma and mitochondrial membranes of hepatocytes in liver cirrhosis. Bull. Exp. Biol. Med. 2021;171(6):690-696. doi: https://doi.org/10.1007/s10517-021-05300-6

    Article  CAS  Google Scholar 

  9. Robinson M, Turnbull S, Lee BY, Leonenko Z. The effects of melatonin, serotonin, tryptophan and NAS on the biophysical properties of DPPC monolayers. Biochim. Biophys. Acta Biomembr. 2020;1862(9):183363. doi: https://doi.org/10.1016/j.bbamem.2020.183363

    Article  CAS  Google Scholar 

  10. Singh M, Chaudhary AK, Pandya S, Debnath S, Singh M, Singh PA, Mehrotra R. Morphometric analysis in potentially malignant head and neck lesions: oral submucous fibrosis. Asian Pac. J. Cancer Prev. 2010;11(1):257-260.

    Google Scholar 

  11. Rebrova TYu, Afanasiev SA, Putrova OD, Popov SV. Age-related features of microviscosity of erythrocyte membranes in experimental cardiosclerosis. Uspekhi Gerontol. 2012;25(4):644-647. Russian.

    Google Scholar 

  12. Sacco A, Belloni L, Latella L. From development to aging: the path to cellular senescence. Antioxid. Redox Signal. 2021;34(4):294-307. doi: https://doi.org/10.1089/ars.2020.8071

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    E. S. Pan, A. V. Pakhomova, N. N. Ermakova, М. А. Zhukova, L. А. Sandrikina, О. D. Putrova, L. V. Kogai, О. V. Pershina, А. М. Dygai & Е. G. Skurikhin

  2. Research Institute of Cardiology, Tomsk National Research Medical Center, Tomsk, Russia

    S. A. Afanas’ev & Т. Yu. Rebrova

  3. Department of Pharmacology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    М. А. Zhukova & L. V. Kogai

  4. Research Institute of General Pathology and Pathophysiology, Moscow, Russia

    А. М. Dygai

Authors
  1. E. S. Pan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. V. Pakhomova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. N. Ermakova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. A. Afanas’ev
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Т. Yu. Rebrova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. М. А. Zhukova
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. L. А. Sandrikina
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. О. D. Putrova
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. L. V. Kogai
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. О. V. Pershina
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. А. М. Dygai
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Е. G. Skurikhin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. S. Pan.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 8, pp. 166-171, August, 2022

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pan, E.S., Pakhomova, A.V., Ermakova, N.N. et al. Age-Related Features of Ketanserin Effects in Experimental Liver Cirrhosis. Bull Exp Biol Med 174, 205–209 (2022). https://doi.org/10.1007/s10517-023-05674-9

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-023-05674-9

Key Words

Search

Navigation