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The Role of Mitochondrial KATP Channels in the Infarct-Reducing Effect of Normobaric Hypoxia

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We studied the role of KATP channels in the infarct-limiting effect of short-term normobaric hypoxia. Male Wistar rats were subjected to a 45-min coronary artery occlusion followed by a 120-min reperfusion. Normobaric hypoxia was simulated 30 min before coronary artery occlusion: 6 sessions of hypoxia (8% O2, 10 min) and reoxygenation (21% O2, 10 min). The following drugs were administered to rats: glibenclamide, 5-hydroxydecanoate, and HMR1098. It was found that normobaric hypoxia contributes to a decrease in myocardial infarct size by 36%. Preliminary administration of glibenclamide or 5-hydroxydecanoate eliminated the infarct-reducing effect of normobaric hypoxia. Activator of mitochondrial KATP channel diazoxide limited the infarct size. These findings suggest that mitochondrial KATP channels are involved into the cardioprotective effect of normobaric hypoxia

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Authors and Affiliations

  1. Research Institute of Cardiology, Tomsk National Research Medical Center, Tomsk, Russia

    L. N. Maslov, A. S. Sementsov, N. V. Naryzhnaya, I. A. Derkachev & S. V. Gusakova

  2. Fourth Military Medical University, Xi’an, China

    F. Fu

  3. Department of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan

    A. Sarybaev

Authors
  1. L. N. Maslov
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  2. A. S. Sementsov
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  3. N. V. Naryzhnaya
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  4. I. A. Derkachev
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  5. F. Fu
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  6. S. V. Gusakova
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  7. A. Sarybaev
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Corresponding author

Correspondence to I. A. Derkachev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 8, pp. 149-153, August, 2022

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Maslov, L.N., Sementsov, A.S., Naryzhnaya, N.V. et al. The Role of Mitochondrial KATP Channels in the Infarct-Reducing Effect of Normobaric Hypoxia. Bull Exp Biol Med 174, 190–193 (2022). https://doi.org/10.1007/s10517-023-05671-y

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  • DOI: https://doi.org/10.1007/s10517-023-05671-y

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