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Angioprotective and Follicle-Stimulating Effects of Administration of Bone Marrow Mesenchymal Stromal Cells in Chronic Inflammation of Internal Reproductive Organs

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Induced inflammation of reproductive organs in female Wistar rats was associated with an increase in the diameters of arteries and veins and number of blood vessels in the ovary medulla in combination with an increase in the number of lymphatic vessels; these changes were accompanied by reduction of the ovarian reserve and number of yellow bodies. Intravenous and submucosal injection of bone marrow multipotent mesenchymal stromal cells (BМ-ММSC) led to further increase in the diameters of arteries and veins and number of primordial and primary follicles. The injection of conditioned medium of BМ-ММSC cultures generally produced the same effects, which could demonstrate the secretory mechanisms of their influence on local angiogenesis and folliculogenesis.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology — Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    Т. I. Dergacheva, Е. V. Starkova, V. V. Klimontov, О. V. Poveschenko & V. I. Konenkov

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  1. Т. I. Dergacheva
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  2. Е. V. Starkova
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  3. V. V. Klimontov
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  4. О. V. Poveschenko
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  5. V. I. Konenkov
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Correspondence to Т. I. Dergacheva.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 90-94, June, 2022

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Dergacheva, Т.I., Starkova, Е.V., Klimontov, V.V. et al. Angioprotective and Follicle-Stimulating Effects of Administration of Bone Marrow Mesenchymal Stromal Cells in Chronic Inflammation of Internal Reproductive Organs. Bull Exp Biol Med 173, 534–538 (2022). https://doi.org/10.1007/s10517-022-05577-1

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  • DOI: https://doi.org/10.1007/s10517-022-05577-1

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