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A Method to Determine Xenobiotic Acetylation Rate by Taq SNP rs1495741

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Drug acetylation plays an important role in the medical practice. Modern methods of acetylation phenotype prediction are based on genotyping of polymorphisms in the second exon of the gene NAT2. Some disadvantages of these methods limit their application in the clinical practice. We developed a method of human genotyping based on identification of NAT2 gene polymorphism rs1495741 by real-time PCR. This method of genotype determination has a number of advantages: high sensitivity, simplicity, possibility of automated interpretation of the results, and feasibility in clinical laboratories.

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Authors and Affiliations

  1. Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russia

    O. B. Ogarkov, E. A. Orlova, P. A. Khromova & S. I. Kolesnikov

  2. Irkutsk State Medical University, Irkutsk, Russia

    N. P. Peretolchina, S. I. Malov, L. A. Stepanenko & I. V. Malov

Authors
  1. O. B. Ogarkov
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  2. N. P. Peretolchina
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  3. S. I. Malov
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  4. E. A. Orlova
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  5. L. A. Stepanenko
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  6. P. A. Khromova
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  7. I. V. Malov
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  8. S. I. Kolesnikov
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Corresponding author

Correspondence to N. P. Peretolchina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 4, pp. 527-531, April, 2022

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Ogarkov, O.B., Peretolchina, N.P., Malov, S.I. et al. A Method to Determine Xenobiotic Acetylation Rate by Taq SNP rs1495741. Bull Exp Biol Med 173, 510–513 (2022). https://doi.org/10.1007/s10517-022-05572-6

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  • DOI: https://doi.org/10.1007/s10517-022-05572-6

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