Skip to main content
SpringerLink
Log in

Reactive Alterations in Thymic Lymphocytopoiesis to Short-Term Decrease in Deuterium Content in the Body

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied changes in thymic lymphocytopoiesis induced by a short-term decrease in deuterium content in the body. The experiment was performed on adult male Wistar rats receiving water with lower deuterium content [D]=10 ppm. Increased relative weight of thymus was found after 24 h of consumption. Flow cytometry revealed higher percentage of undifferentiated cells and mature T cells, especially cytotoxic T cells. Hence, lymphocytopoiesis in the thymus is highly sensitive to short-term decrease in deuterium body content. A decrease in the content of deuterium stimulates proliferation of lymphoblasts in the thymus and slows down migration of differentiated T cells. Enhanced generation of cytotoxic T cells under these conditions attests to the role of deuterium in selection of double-positive thymocytes. The revealed shifts are reactive, and their pattern can change later, which requires further research.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Rakov DV. Alleviation of gamma-radiation damage by water with reduced deuterium and 18О. Aviakosm. Ekolog. Med. 2007;41(3):36-39. Russian.

    CAS  PubMed  Google Scholar 

  2. Yaglova NV, Obernikhin SS, Timokhina EP, Yaglov VV. Response of pituitary-thyroid axis to short-term shift in deuterium body content. Bull. Exp. Biol. Med. 2021;171(2):262-264. doi: https://doi.org/10.1007/s10517-021-05208-1

    Article  CAS  PubMed  Google Scholar 

  3. Bild W, Năstasă V, Haulică I. In vivo and in vitro research on the biological effects of deuterium-depleted water: 1. Influence of deuterium-depleted water on cultured cell growth. Rom. J. Physiol. 2004;41(1-2):53-67.

    CAS  PubMed  Google Scholar 

  4. Boros LG, Somlyai I, Kovács BZ, Puskás LG, Nagy LI, Dux L, Farkas G, Somlyai G. Deuterium depletion inhibits cell proliferation, RNA and nuclear membrane turnover to enhance survival in pancreatic cancer. Cancer Control. 2021;28:1073274821999655. doi: https://doi.org/10.1177/1073274821999655

    Article  PubMed  PubMed Central  Google Scholar 

  5. Cong FS, Zhang YR, Sheng HC, Ao ZH, Zhang SY, Wang JY. Deuterium-depleted water inhibits human lung carcinoma cell growth by apoptosis. Exp. Ther. Med. 2010;1(2):277-283. doi: https://doi.org/10.3892/etm_00000043

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Dzhimak SS, Basov AA, Fedulova LV, Didikin AS, Bikov IM, Arcybasheva OM, Naumov GN, Baryshev MG. Correction of metabolic processes in rats during chronic endotoxicosis using isotope (D/H) exchange reactions. Izv. Akad. Nauk Ser. Biol. 2015;(5):518-527.

    Google Scholar 

  7. Klein L, Kyewski B, Allen PM, Hogquist KA. Positive and negative selection of the T cell repertoire: what thymocytes see (and don’t see). Nat. Rev. Immunol. 2014;14(6):377-391. doi: https://doi.org/10.1038/nri3667

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kondo K, Ohigashi I, Takahama Y. Thymus machinery for T-cell selection. Int. Immunol. 2019;31(3):119-125. doi: https://doi.org/10.1093/intimm/dxy081

    Article  CAS  PubMed  Google Scholar 

  9. Yaglova NV, Obernikhin SS, Yaglov VV, Nazimova SV. Time-dependent effect of deuterium depletion on tumor growth and metastasis. Russ. Open Med. J. 2020;9(2):e0210. doi: https://doi.org/10.15275/rusomj.2020.0210

    Article  CAS  Google Scholar 

  10. Zhang X, Gaetani M, Chernobrovkin A, Zubarev RA. Anticancer effect of deuterium-depleted water — redox disbalance leads to oxidative stress. Mol. Cell. Proteomics. 2019;18(12):2373-2387. doi: https://doi.org/10.1074/mcp.RA119.001455

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Zhang X, Wang J, Zubarev RA. Slight deuterium enrichment in water acts as an antioxidant: is deuterium a cell growth regulator? Mol. Cell. Proteomics. 2020;19(11):1790-1804. doi: https://doi.org/10.1074/mcp.RA120.002231

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. A. P. Avtsyn Research Institute of Human Morphology, B. V. Pet-rovsky Russian Research Centre of Surgery, Moscow, Russia

    N. V. Yaglova, S. S. Obernikhin, E. P. Timokhina, S. V. Nazimova & V. V. Yaglov

Authors
  1. N. V. Yaglova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. S. Obernikhin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. P. Timokhina
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. V. Nazimova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. V. Yaglov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. V. Yaglova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 4, pp. 508-511, April, 2022

Rights and permissions

Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yaglova, N.V., Obernikhin, S.S., Timokhina, E.P. et al. Reactive Alterations in Thymic Lymphocytopoiesis to Short-Term Decrease in Deuterium Content in the Body. Bull Exp Biol Med 173, 494–496 (2022). https://doi.org/10.1007/s10517-022-05568-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-022-05568-2

Key Words

Search

Navigation