We studied the brain of 5- and 14-day-old intact (control group) rats and rats of the same age from litters experimentally reduced on days 1 and 5 after birth (experimental groups). In animals of both experimental subgroups, the brain had morphological signs of advanced development: greater weight of the brain and hemisphere, greater thickness of the cortex, its molecular layer, lower numerical density of neurons in the anterior parietal and proper parietal lobes, greater sizes of neurons, their nuclei, and nucleoli in the neocortex of these zones, and increased concentration of RNA in the cytoplasm of neurons. These data suggest that the rate of brain development in rats can be accelerated under the influence of environmental changes that occur after litter reduction during the neonatal period at different times after birth.
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References
Gomazkov OA. Neurogenesis as an Adaptive Function of Brain. Moscow, 2013. Russian.
Dement’eva GM. Children with Intrauterine Growth Retardation. Neonatology. National Guidelines. Moscow, 2007. P. 127-133. Russian.
Koterov AN, Ushenkova LN, Zubenkova ES, Wainson AA, Andrianova IE, Lukyanova SN, Lyaginskaya AM, Mal’tsev VN, Ilyin LA, Samoylov AS, Uiba VV. Acceleration of laboratory rats: synthetic study of data for the century in the aspect of possible relationship with radiosensitivity. Med. Radiol. Radiats. Bezopasnost. 2018;63(6):5-20. Russian. doi: 10.12737/article_5c0b88579b10a6.86596118
Perminova AA, Zinserling VA. Neurogenesis in the adult human brain: morphological aspects. Arkh. Patol. 2018;80(6):55-61. Russian. doi: 10.17116/patol20188006155
Ryzhavskii BYa. Brain Development: Delayed Effects of Non-Comfort Conditions. Khabarovsk, 2009. Russian.
Ryzhawskii BYa, Zhl’nikov DI. Effect of Experimental Litters Reduction during the Neonatal and Milk Periods of Ontogeny on Some Parameters of Brain Development in 30-Day-Old Rats. Bull. Exp. Biol. Med. 2022;172(4):490-494. doi: https://doi.org/10.1007/s10517-022-05420-7
Ryzhavskii BYa, Lebed’ko OA, Lazinskaya OV. Immediate and delayed effects of food restriction on some parameters of brain development in rats. Bull. Exp. Biol. Med. 2019;167(1)104-110. doi: https://doi.org/10.1007/s10517-019-04471-7
Trukhina SI, Tsirkin VI, Khlybova SV, Trukhin AN. The successfulness of study of children in the 1-8 grades of a secondary school who have low body weight at birth. Med. Almanakh. 2010;(4):219-223. Russian.
Tsekhmistrenko TA, Kozlov VI. Histophysiologic approach in the study of the structural organization of the human cerebral cortex in ontogenesis. Tikhookean. Med. Zh. 2016;(2):103-107. Russian.
Clancy B, Darlington RB, Finlay BL. Translating developmental time across mammalian species. Neuroscience. 2001;105(1):7-17. doi: https://doi.org/10.1016/s0306-4522(01)00171-3
Clayton PE, Cianfarani S, Czernichow P, Johannsson G, Rapaport R, Rogol A. Therapy in low birth weight babies for this term of pregnancy (SGA) until they attain adult age: Consensus agreement of the International Community of Pediatric Endocrinologists and the International Society on the Study of Growth Hormone. Problemy Endokrinol. 2008;54(1):51-55. Russian.doi: 10.14341/probl200854151-55
Erhard HW, Boissy A, Rae MT, Rhind SM. Effects of prenatal undernutrition on emotional reactivity and cognitive flexibility in adult sheep. Behav. Brain Res. 2004;151(1-2):25-35. doi: https://doi.org/10.1016/j.bbr.2003.08.003
Fukuda MT, Françolin-Silva AL, Almeida SS. Early postnatal protein malnutrition affects learning and memory in the distal but not in the proximal cue version of the Morris water maze. Behav. Brain Res. 2002;133(2):271-277. doi: https://doi.org/10.1016/s0166-4328(02)00010-4
McKenna MC, Scafidi S, Robertson CL. Metabolic Alterations in Developing Brain After Injury: Knowns and Unknowns. Neurochem. Res. 2015;40(12):2527-2543. doi: https://doi.org/10.1007/s11064-015-1600-7
Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. New York, 2006.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 4, pp. 486-492, April, 2022
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Ryzhavskii, B.Y., Zhilnikov, D.I. & Lazinskaya, O.V. Influence of Litter Reduction in the Neonatal Period at Different Times after Birth on the Parameters of Brain Development in Rats. Bull Exp Biol Med 173, 475–480 (2022). https://doi.org/10.1007/s10517-022-05564-6
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DOI: https://doi.org/10.1007/s10517-022-05564-6