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Autophagy in Human Retinal Neurons in Glaucoma

  • MORPHOLOGY AND PATHOMORPHOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Immunohistochemical and ultrastructural analysis revealed signs of structural alterations in neurons and autophagy in all layers of the human retina at the end-stage glaucoma. The most pronounced destructive changes associated with swelling and destruction of mitochondria, endoplasmic reticulum, and Golgi apparatus, as well as structural signs of impaired synaptic activity and apoptosis were noted in ganglion, bipolar, and amacrine neurons. In the structure of photoreceptor cells, alone with destructive processes associated with structural alterations of rods and cones in the outer membrane discs, as well as swelling of organelles, we observed processes aimed at the maintenance of cell homeostasis. Structural signs of autophagy (mainly mitophagy) and changes of the ultrastructural organization in rod neurons were more pronounced than in cones.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    N. A. Obanina & N. P. Bgatova

  2. S. N. Fyodorov Eye Microsurgery Federal State Institution of the Russian Ministry of Health — Novosibirsk Branch, Novosibirsk, Russia

    A. V. Eremina, A. N. Trunov & V. V. Chernykh

Authors
  1. N. A. Obanina
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  2. N. P. Bgatova
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  3. A. V. Eremina
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  4. A. N. Trunov
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  5. V. V. Chernykh
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Corresponding author

Correspondence to A. N. Trunov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 4, pp. 479-485, April, 2022

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Obanina, N.A., Bgatova, N.P., Eremina, A.V. et al. Autophagy in Human Retinal Neurons in Glaucoma. Bull Exp Biol Med 173, 468–474 (2022). https://doi.org/10.1007/s10517-022-05563-7

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  • DOI: https://doi.org/10.1007/s10517-022-05563-7

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