In chronic experiments on calves, the effect of the left-ventricular assist device (LVAD) technique by using a disc pump on the indicators of ionic and acid-base homeostasis. At blood velocity of 20% from the total volume, a trend towards an increase in K+ concentration and a slight decrease in the concentration of Na+, pH, and standard base excess in animal plasma were observed. If the blood velocity increased up to 90%, the indicators of ionic and acid-base homeostasis returned to their baseline values. In parallel, stroke volume and cardiac output as well as BP at the outlet of the heart and inside it and HR increased simultaneously with a blood pressure decrease in the input cannula site. There were no differences in plasma concentrations of Ca2+ and Cl- at different blood flow volumes.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 3, pp. 390-394, March, 2022
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Golovina, K.O., Golovin, A.M. & Aizman, R.I. Parameters of Ionic and Acid-Base Balance during Assist Circulation with a LVAD Disc Pump. Bull Exp Biol Med 173, 390–393 (2022). https://doi.org/10.1007/s10517-022-05555-7
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DOI: https://doi.org/10.1007/s10517-022-05555-7