Skip to main content

Analysis of Electrophysiological Mechanisms of N-Deacetyllapaconitine Monochlorhydrate, the Main Metabolite of Lappaconitine Hydrobromide

In in vitro experiments on isolated rat hippocampal neurons, we studied the electrophysiological mechanisms of the antiarrhythmic effects of N-deacetyllappaconitine monochlorhydrate (DALCh), active metabolite of lappaconitine hydrobromide (allapinin). Electrical activity of neurons was recorded by the patch-clamp method in the whole cell configuration. It was shown that DALCh increased the duration of both slow and fast depolarization phases and decreased the amplitude of the action potential. DALCh effectively inhibited transmembrane currents of Na+ ions and partially K+ ions through the corresponding transmembrane voltage-gated ion channels. Thus, DALCh, in contrast to lappaconitine hydrobromide, belongs not to 1C, but to the 1A class of antiarrhythmics according to the Vaughan-Williams classification.

This is a preview of subscription content, access via your institution.


  1. Kryzhanovskii SA, Vititnova MB. Antiarrhythmic Drugs. Moscow, 2008. Russian.

  2. Sokolov SF. Allapinin® and modern approaches to the treatment of cardiac arrhythmias. Russ. Med. Zh. 2012;(4):177-184. Russian.

    Google Scholar 

  3. Sokolov SF, Dzhakhangirov FN. Antiarrhythmic drug allapinin: review of results of clinical investigation. Kardiologiia. 2002;42(7):96-102. Russian.

    CAS  PubMed  Google Scholar 

  4. Tsorin IB, Zinchenko VP, Teplov IYu, Kosenkov AM, Murinov YuI, Yunusov MS, Kryzhanovskii SA. The study of electrophysiological mechanisms of the action compounds LMG-124. Farmakokinetika. Farmakodinamika. 2017;(2):4-11. Russian.

    Google Scholar 

  5. Pott C, Dechering DG, Muszynski A, Zellerhoff S, Bittner A, Wasmer K, Mönnig G, Eckardt L. Class I antiarrhythmic drugs: mechanisms, contraindications, and current indications. Herzschrittmacherther Elektrophysiol. 2010;21(4):228-238. doi:

    CAS  Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to I. B. Tsorin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 2, pp. 193-198, February, 2022

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Tsorin, I.B., Teplov, I.Y., Zinchenko, V.P. et al. Analysis of Electrophysiological Mechanisms of N-Deacetyllapaconitine Monochlorhydrate, the Main Metabolite of Lappaconitine Hydrobromide. Bull Exp Biol Med 173, 219–223 (2022).

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI:

Key Words

  • metabolite of lappaconitine hydrobromide monochlorohydrate N-deacetyllappaconitine
  • patch-clamp
  • action potential
  • Na+ ion currents
  • K+ ion currents