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Pharmacokinetic Parameters of Oral Pegylated IFN-λ1

We studied the pharmacokinetics of a pegylated IFN-λ1 (PEG IFN-λ1) after its oral administration to rats in different therapeutic doses. The hypothesis on linear pharmacokinetics of PEG IFN-λ1 within the dose range of 2.6-7.8 μg/kg was confirmed, high for protein molecules bioavailability from 17.5 to 21%, the absence of intravascular deposition, and effective elimination with feces and urine (85 and 15% of the administered dose, respectively) were demonstrated. At the same time, the mean retention time for PEG IFN-λ1 in the circulation is 6.46-6.65 h and half-life is 3 h. These findings give ground for continuing experimental studies of PEG IFN-λ1 pharmacokinetics, in particular, tissue distribution of the drug.

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Correspondence to E. Yu. Sherstoboev.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 2, pp. 188-192, February, 2022

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Sherstoboev, E.Y., Oleinik, L.A., Zhdanov, V.V. et al. Pharmacokinetic Parameters of Oral Pegylated IFN-λ1. Bull Exp Biol Med 173, 215–218 (2022). https://doi.org/10.1007/s10517-022-05521-3

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  • DOI: https://doi.org/10.1007/s10517-022-05521-3

Key Words

  • interferon lambda
  • pegylated interferon lambda 1 (PEG IFN-λ1)
  • pharmacokinetic