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Early Diagnostic Markers and Therapeutic Targets for Experimental Breast Cancer

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Bulletin of Experimental Biology and Medicine Aims and scope

Various stem cells were studied in female BALB/c mice at the early terms after administration of N-methyl-N-nitrosourea to search early diagnostic markers and therapeutic targets. At these terms, damage to the epithelium and endothelium, inflammation, and fibrosis were observed in the mammary gland, but the tumor was not detected. Cancer stem cells, hematopoietic stem cells (HSC), hematopoietic progenitor cells, angiogenic precursors, and epithelial progenitor cells were found in the blood and mammary gland. Cancer stem cells (CD44+CD24—) are proposed as the early diagnostic marker of breast cancer, and short-living HSC, hematopoietic progenitor cells, and angiogenic precursors (CD45—CD117+FLK-1+) as predictors of the formation of tumor microenvironment.

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Authors and Affiliations

  1. Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    N. N. Ermakova, O. V. Pershina, M. A. Zhukova, A. V. Pakhomova, E. S. Pan, L. A. Sandrikina, V. A. Krupin, O. Yu. Rybalkina, A. M. Dygai & E. G. Skurikhin

  2. Research Institute of General Pathology and Pathophysiology, Moscow, Russia

    A. M. Dygai

Authors
  1. N. N. Ermakova
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  2. O. V. Pershina
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  3. M. A. Zhukova
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  4. A. V. Pakhomova
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  5. E. S. Pan
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  6. L. A. Sandrikina
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  7. V. A. Krupin
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  8. O. Yu. Rybalkina
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  9. A. M. Dygai
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  10. E. G. Skurikhin
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Corresponding author

Correspondence to E. G. Skurikhin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 12, pp. 750-755, December, 2021

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Ermakova, N.N., Pershina, O.V., Zhukova, M.A. et al. Early Diagnostic Markers and Therapeutic Targets for Experimental Breast Cancer. Bull Exp Biol Med 172, 747–751 (2022). https://doi.org/10.1007/s10517-022-05470-x

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  • DOI: https://doi.org/10.1007/s10517-022-05470-x

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