The effect of probiotic therapy on the main hemodynamic parameters was studied in Wistar rats with modeled syndrome of systemic inflammatory response resulting from chemically induced colitis complicated by antibiotic-induced dysbiosis. Using a wireless telemetry monitoring system in round-the-clock mode, the mean systolic and diastolic BP, HR, and body temperature were measured over 27 days. In the group of animals receiving no probiotics, a significant decrease in feed consumption and body weight loss were observed. By the end of the experiment, BP in this group was lower by 12% and HR was higher by 10% than in the control. In animals treated with a mixture of probiotic strains Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis, all the studied parameters returned to the initial values. Thus, we demonstrated the possibility of using probiotic drugs for the treatment of acute systemic inflammatory process, which should be considered in the development of new treatment protocols in veterinary and medicine.
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Averina OV, Ermolenko EI, Ratushniy AYu, Tarasova EA, Borschev YuYu, Leontieva GF, Kramskaya TA, Kotyleva MP, Danilenko VN, Suvorov AN. Influence of probiotics on cytokine production in the in vitro and in vivo systems. Med. Immunol. 2015;17(5):443-454. https://doi.org/10.15789/1563-0625-2015-5-443-454. Russian.
Borschev YuYu, Burovenko IYu, Karaseva AB, Minasyan SM, Borschev VYu, Semenova NYu, Borshcheva OV, Polovinkin VV, Rodionov GG, Suvorov AN, Galagudza MM. Modeling of systemic inflammatory response syndrome by chemical induction of colon injury in rats. Med. Immunol. 2020;22(1):87-98. https://doi.org/10.15789/1563-0625-MOS-1839. Russian.
Borschev YuYu, Burovenko IYu, Karaseva AB, Minasyan SM, Protsak ES, Borschev VYu, Semenova NYu, Borshcheva OV, Suvorov AN, Galagudza MM. Effect of the qualitative composition of a high-fat diet in rats with systemic inflammatory response syndrome upon myocardial resistance to ischemic-reperfusion injury and cytokine levels. Med. Immunol. 2021;23(5):1091-1106. https://doi.org/10.15789/1563-0625-EOT-2166. Russian.
Intestine Dysbiosis. Guidelines on Diagnostics and Treatment. Tkachenko EI, Suvorov AN, eds. St. Peterburg, 2009. Russian.
Tkachenko EI, Uspenskii YuP. Nutrition, Microbiocenosis, and Human Intelligence. St. Peterburg, 2006. Russian.
Borshchev YY, Sinitsa AV, Zakharchenko MM, Borshchev VY, Burovenko IY, Galagudza MM. Effect of antiobiotic-induced disbiosis and its correction with probiotics on myocardial tolerance to ischemia-reperfusion injury in SPF rats. Bull. Exp. Biol. Med. 2019;166(4):440-443. https://doi.org/10.1007/s10517-019-04368-5
Bron PA, Kleerebezem M, Brummer RJ, Cani PD, Mercenier A, MacDonald TT, Garcia-Ródenas CL, Wells JM. Can probiotics modulate human disease by impacting intestinal barrier function? Br. J. Nutr. 2017;117(1):93-107. https://doi.org/10.1017/S0007114516004037.
Cani PD, Osto M, Geurts L, Everard A. Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity. Gut Microbes. 2012;3(4):279-288. https://doi.org/10.4161/gmic.19625
Caruso R, Lo BC, Núñez G. Host-microbiota interactions in inflammatory bowel disease. Nat. Rev. Immunol. 2020;20(7):411-426. https://doi.org/10.1038/s41577-019-0268-7
Dieleman LA, Palmen MJ, Akol H, Bloemena E, Peña AS, Meuwissen SG, Van Rees EP. Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin. Exp. Immunol. 1998;114(3):385-391. https://doi.org/10.1046/j.1365-2249.1998.00728.x
Lee HJ, Choi JK, Ryu HS, Choi CH, Kang EH, Park KS, Min YW, Hong KS. Therapeutic modulation of gut microbiota in functional bowel disorders. J. Neurogastroenterol. Motil. 2017;23(1):9-19. https://doi.org/10.5056/jnm16124
Pourafkari L, Masnadi-Shirazi K, Taban M, Mohammadi S, Parizad R, Ghaffari S, Tajlil A, Khoshknab MMP, Nader ND. Higher frequency of nocturnal blood pressure dipping but not heart rate dipping in inflammatory bowel disease. Dig. Dis. Sci. 2017;62(10):2863-2869. https://doi.org/10.1007/s10620-017-4712-x
Tang WH, Kitai T, Hazen SL. Gut microbiota in cardiovascular health and disease. Circ. Res. 2017;120(7):1183-1196. https://doi.org/10.1161/CIRCRESAHA.117.309715
Tilg H, Kaser A. Gut microbiome, obesity, and metabolic dysfunction. J. Clin. Invest. 2011;121(6):2126-2132. https://doi.org/10.1172/JCI58109
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 12, pp. 669-674, December, 2021
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Borshchev, Y.Y., Protsak, E.S., Burovenko, I.Y. et al. Effect of Probiotic Therapy on Hemodynamic Response Associated with Systemic Inflammatory Reaction and Antibiotic-Induced Dysbiosis in Chronic Experiments in Rats. Bull Exp Biol Med 172, 676–680 (2022). https://doi.org/10.1007/s10517-022-05455-w
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DOI: https://doi.org/10.1007/s10517-022-05455-w