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Parameters of Oxidative Stress and Activity of Antioxidant Enzymes in the Saliva of Patients with Type 1 Diabetes Mellitus

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Glucose concentration in the saliva is increased in type 1 diabetes mellitus. This parameter directly correlates with markers of the disease in the blood serum. Increased concentration of 8-oxo-2’-deoxyguanosine (8-OHdG) and diene conjugates, markers of oxidative stress, and reduced activities of superoxide dismutase and catalase were also observed in this pathology. Correlation analysis revealed a strong positive correlation between glucose concentration and the levels of oxidative stress markers and a negative correlation between activity of antioxidant enzymes and glucose concentration. The results indicate that the level of 8-OHdG, diene conjugates, and superoxide dismutase and catalase activities can serve as diagnostic markers of pathophysiological changes in the body in type 1 diabetes mellitus.

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Authors and Affiliations

  1. N. N. Burdenko Voronezh State Medical University, Ministry of the Health of the Russian Federation, Voronezh, Russia

    A. A. Cheprasova, S. S. Popov & A. N. Pashkov

  2. Voronezh State University, Voronezh, Russia

    A. N. Verevkin & K. K. Shul’gin

Authors
  1. A. A. Cheprasova
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  2. S. S. Popov
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  3. A. N. Pashkov
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  4. A. N. Verevkin
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  5. K. K. Shul’gin
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Corresponding author

Correspondence to A. A. Cheprasova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 11, pp. 586-592, November, 2021

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Cheprasova, A.A., Popov, S.S., Pashkov, A.N. et al. Parameters of Oxidative Stress and Activity of Antioxidant Enzymes in the Saliva of Patients with Type 1 Diabetes Mellitus. Bull Exp Biol Med 172, 552–557 (2022). https://doi.org/10.1007/s10517-022-05431-4

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  • DOI: https://doi.org/10.1007/s10517-022-05431-4

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