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New Carbon-Mineral Sorbent Based on Aluminum Oxide, Polydimethylsiloxane, and Single-Wall Carbon Nanotubes: Assessment of the Effect on Erythrocytes In Vitro

  • BIOTECHNOLOGIES
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Bulletin of Experimental Biology and Medicine Aims and scope

A comparative study of the effect of a sorbent with nanotubes (Al2O3@ WCNT-PDMS) and a carbon-mineral sorbent (Al2O3@C) on the parameters of human erythrocytes was carried out. Using scanning flow cytometry, the morphological and functional parameters of venous blood erythrocytes as well as drainage blood after its perfusion through columns with sorbents were determined. The compared samples Al2O3@SWCNT-PDMS and Al2O3@C are similar by their effect on the morphological and functional parameters of erythrocytes. The maximum membrane extensibility increased to a greatest extent after contact with Al2O3@C, the amount of hemoglobin in erythrocytes decreased to the greatest extent after perfusion through a column with Al2O3@SWCNT-PDMS sorbent. The scanning flow cytometry is promising for assessing the effect on erythrocytes of new sorption materials intended for blood detoxification. Changes in the parameters of erythrocytes of blood collected in a sterile drainage system for subsequent reinfusion were revealed.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology — Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    V. V. Nimaev, A. V. Pivkina, A. V. Shurlygina, L. N. Rachkovskaya, A. A. Smagin, E. S. Yastrebova, E. E. Rachkovskii, M. A. Korolev, V. P. Mal’tsev & A. Yu. Letyagin

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  1. V. V. Nimaev
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  2. A. V. Pivkina
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  3. A. V. Shurlygina
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  4. L. N. Rachkovskaya
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  5. A. A. Smagin
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  6. E. S. Yastrebova
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  7. E. E. Rachkovskii
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  8. M. A. Korolev
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  9. V. P. Mal’tsev
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  10. A. Yu. Letyagin
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Correspondence to V. V. Nimaev.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 10, pp. 495-500, October, 2021

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Nimaev, V.V., Pivkina, A.V., Shurlygina, A.V. et al. New Carbon-Mineral Sorbent Based on Aluminum Oxide, Polydimethylsiloxane, and Single-Wall Carbon Nanotubes: Assessment of the Effect on Erythrocytes In Vitro. Bull Exp Biol Med 172, 478–482 (2022). https://doi.org/10.1007/s10517-022-05417-2

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  • DOI: https://doi.org/10.1007/s10517-022-05417-2

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