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Analysis of Antibacterial Action of Mammalian Host-Defense Cathelicidins and Induction of Resistance to Them in MβL-Producing Pseudomonas aeruginosa

  • IMMUNOLOGY AND MICROBIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Recombinant analogs of a number of natural host-defense mammalian cathelicidins were obtained and predominant mechanism of their antibacterial action was studied. The ability of cathelicidins to suppress the growth of Pseudomonas aeruginosa producing metallo-β-lactamases (MβL) was studied, and the possibility of appearance of cathelicidin-resistant bacteria was evaluated. Among peptides with different structures and mechanisms of action, only the strains resistant to ChMAP-28 were not obtained, which indicated minimum risk of the development of natural resistance to this cathelicidin. High antibacterial activity, wide spectrum of action, and the absence of cross-resistance effects allow considering ChMAP-28 peptide as a candidate to be developed further as a therapeutic agent against MβL-producing bacteria.

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Authors and Affiliations

  1. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    P. V. Panteleev, I. A. Bolosov, V. A. Khokhlova, S. V. Balandin & T. V. Ovchinnikova

  2. Antimicrobial Research Laboratory, New Chemistry Unit and School of Advanced Materials, Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR), Jakkur, Bangalore, India

    G. Dhanda & J. Haldar

Authors
  1. P. V. Panteleev
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  2. I. A. Bolosov
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  3. V. A. Khokhlova
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  4. G. Dhanda
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  5. S. V. Balandin
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  6. J. Haldar
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  7. T. V. Ovchinnikova
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Corresponding author

Correspondence to T. V. Ovchinnikova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 10, pp. 459-465, October, 2021

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Panteleev, P.V., Bolosov, I.A., Khokhlova, V.A. et al. Analysis of Antibacterial Action of Mammalian Host-Defense Cathelicidins and Induction of Resistance to Them in MβL-Producing Pseudomonas aeruginosa. Bull Exp Biol Med 172, 447–452 (2022). https://doi.org/10.1007/s10517-022-05411-8

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  • DOI: https://doi.org/10.1007/s10517-022-05411-8

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