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Preclinical Pharmacokinetics of GZK-111, a Dipeptide with Neuroprotective Activity

  • PHARMACOLOGY AND TOXICOLOGY
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We studied the pharmacokinetics of GZK-111 (N-phenylacetyl-glycyl-L-proline ethyl ether), a compound with neuroprotective activity, and its metabolite CPG (cyclo-L-prolylglycine) in rat blood plasma after single intravenous and intragastric administration in a dose of 20 mg/kg. It was found that the parent drug undergoes intensive biotransformation; its metabolite CPG persists in the circulation more than twice as long as GZK-111 and its plasma concentrations were higher by 50-70 times than the concentrations of the parent compound.

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Authors and Affiliations

  1. Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia

    A. A. Litvin, G. B. Kolyvanov, P. O. Bochkov, R. V. Shevchenko, A. L. Podol’ko, K. N. Kolyasnikova & V. P. Zherdev

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  1. A. A. Litvin
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  2. G. B. Kolyvanov
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  3. P. O. Bochkov
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  4. R. V. Shevchenko
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  5. A. L. Podol’ko
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  6. K. N. Kolyasnikova
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  7. V. P. Zherdev
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Correspondence to A. A. Litvin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 9, pp. 298-302, September, 2021

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Litvin, A.A., Kolyvanov, G.B., Bochkov, P.O. et al. Preclinical Pharmacokinetics of GZK-111, a Dipeptide with Neuroprotective Activity. Bull Exp Biol Med 172, 310–313 (2022). https://doi.org/10.1007/s10517-022-05400-x

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  • DOI: https://doi.org/10.1007/s10517-022-05400-x

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