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Effects of Boron Neutron Capture Therapy on the Growth of Subcutaneous Xenografts of Human Colorectal Adenocarcinoma SW-620 in Immunodeficient Mice

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Bulletin of Experimental Biology and Medicine Aims and scope

Boron neutron capture therapy (BNCT) can become an instrument for patients with malignant neoplasms of the rectum and colon. Here we evaluate the effectiveness of BNCT performed at the accelerator based epithermal neutron source at G. I. Budker Institute of Nuclear Physics, Siberian Division of Russian Academy of Sciences, in relation to subcutaneous xenografts of human colon adenocarcinoma SW-620 in SCID mice. Utilization of BNCT with boronоphenylalanine (BPA) and sodium borocaptate (BSH), which were injected intravenously into the retroorbital sinus, resulted in a significant decrease in tumor volumes compared to the control group (no radiation).

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Authors and Affiliations

  1. Novosibirsk National Research State University, Novosibirsk, Russia

    V. V. Kanygin, A. I. Kasatova, E. L. Zavjalov, I. A. Razumov, A. I. Kichigin, O. I. Solov’eva, A. R. Tsygankova, S. Yu. Taskaev, D. A. Kasatov & T. V. Sycheva

  2. G. I. Budker Institute of Nuclear Physics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia

    A. I. Kasatova, S. Yu. Taskaev, D. A. Kasatov & T. V. Sycheva

  3. Federal Research Centre Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia

    E. L. Zavjalov, I. A. Razumov & O. I. Solov’eva

  4. Research Center for Problems of Family Health and Human Reproduction, Irkutsk, Russia

    S. I. Kolesnikov

  5. M. V. Lomonosov Moscow State University, Moscow, Russia

    S. I. Kolesnikov

  6. A. V. Nikolaev Institute of Inorganic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia

    A. R. Tsygankova

  7. Irkutsk State Medical University, Ministry of Health of the Russian Federation, Irkutsk, Russia

    V. A. Byvaltsev

  8. Irkutsk State Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, Irkutsk, Russia

    V. A. Byvaltsev

Authors
  1. V. V. Kanygin
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  2. A. I. Kasatova
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  3. E. L. Zavjalov
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  4. I. A. Razumov
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  5. S. I. Kolesnikov
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  6. A. I. Kichigin
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  7. O. I. Solov’eva
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  8. A. R. Tsygankova
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  9. S. Yu. Taskaev
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  10. D. A. Kasatov
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  11. T. V. Sycheva
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  12. V. A. Byvaltsev
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Corresponding author

Correspondence to V. A. Byvaltsev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 9, pp. 356-361, September, 2021

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Kanygin, V.V., Kasatova, A.I., Zavjalov, E.L. et al. Effects of Boron Neutron Capture Therapy on the Growth of Subcutaneous Xenografts of Human Colorectal Adenocarcinoma SW-620 in Immunodeficient Mice. Bull Exp Biol Med 172, 359–363 (2022). https://doi.org/10.1007/s10517-022-05392-8

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  • DOI: https://doi.org/10.1007/s10517-022-05392-8

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