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Reparative and Immunomodulatory Potential of Low-Molecular-Weight Fractions of Secondary Metabolites of Bacillus sp.

  • IMMUNOLOGY AND MICROBIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

The experiment was performed on male BALB/c mice with modeled skin wound. Two chromatographic fractions of secondary metabolites of permafrost bacteria Bacillus sp., that represent a mixture of polyethylene-polypropylene glycols oligomers with a molecular weight from 900 to 1350 Da were used as therapeutic agents. Application of the test substances on the wound surface and their parenteral administration significantly accelerated wound epithelialization in comparison with untreated control, activated metabolic processes, and improved humoral immunity. In in vitro experiments, the fractions activated the synthesis of IFNγ and IL-4 by human peripheral blood mononuclear cells. We conclude that polyethylene-polypropylene glycol oligomers can be a part of effector molecules that determine the repair and immunomodulatory potential of secondary metabolites of permafrost microorganisms Bacillus sp.

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Authors and Affiliations

  1. Federal Research Center Tyumen Scientific Center, Siberian Division of the Russian Academy of Sciences, Tyumen, Russia

    L. F. Kalenova, S. A. Petrov & Yu. G. Sukhovei

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  1. L. F. Kalenova
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  2. S. A. Petrov
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  3. Yu. G. Sukhovei
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Correspondence to L. F. Kalenova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 9, pp. 323-327, September, 2021

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Kalenova, L.F., Petrov, S.A. & Sukhovei, Y.G. Reparative and Immunomodulatory Potential of Low-Molecular-Weight Fractions of Secondary Metabolites of Bacillus sp.. Bull Exp Biol Med 172, 332–335 (2022). https://doi.org/10.1007/s10517-022-05387-5

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  • DOI: https://doi.org/10.1007/s10517-022-05387-5

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